行为治疗辅助普拉克索对早发帕金森病伴抑郁患者抑郁程度和非运动症状的影响

Effect of behavioral therapy combined with pramipexole on the degree of depression and non-motor symptoms in early-onset Parkinson's disease and depression

目的探讨普拉克索辅助行为疗法治疗早发帕金森病伴抑郁患者对患者抑郁程度和非运动症状的影响效果。方法选取2010年1月~2015年12月收治的30例帕金森伴抑郁患者,平均分为观察组和对照组各15例,所有患者入组后均给予普拉克索,观察组患者在普拉可索治疗基础上给予行为治疗。均连续治疗12周后用汉密尔顿抑郁量表（HAMD）、Zung抑郁自评量表和统一帕金森评分量表（UPDRS）比较2组患者治疗前后抑郁程度和非运动症状的改善效果。结果治疗前2组患者HAMD评分、Zung评分、UPDRS II评分以及UPDRS III评分无显著差异,治疗后各项评分均较治疗前显著下降（P〈0.05）;治疗4周后2组患者HAMD评分、Zung评分无显著差异,治疗后第8~12周末观察组患者HAMD评分、Zung评分均显著优于对照组（P〈0.05）;治疗4~8周后2组患者UPDRSII评分和UPDRS III评分无显著差异,治疗后第12周末观察组UPDRS II评分以及UPDRS III评分显著优于对照组（P〈0.05）。结论行为治疗辅助普拉克索治疗早发帕金森伴抑郁患者有助于改善患者的抑郁情况,对非运动症状亦有明显的抑制作用,对早发帕金森伴抑郁患者的生活质量的改善具有重要意义。

Objective To discuss the clinical effect of behavioral therapy combined with pramipexole in patients＇ degree of depression and nonmotor symptoms in early-onset Parkinson＇s disease and depression. Methods A total of 74 cases of patients with early-onset Parkinson＇s disease and depression were equally divided into observation group and control group,37 cases in each groups. Patients in control group were given pramipexole,while patients in observation group were given pramipexole and behavioral therapy. The hamilton depression（ HAMD） scale,Zung self-rating depression scale and unified Parkinson＇s disease rating scale（ UPDRS） were used to evaluate and measure the change of degree of depression and non-motor symptoms. Results Before treatment,the HAMD score,Zung score,UPDRS II score and UPDRS III score between two groups had no statistical difference; after treatment,the HAMD score,Zung score,UPDRS II score and UPDRS III score in two groups were significantly decreased（ P〈0. 05）.The HAMD score,and Zung score between two groups had no statistical difference at the end of 4th weekends,and compared with control group,those scores in observation group were much better at the end of 8th and 12 th weekend（ P〈0. 05）. The UPDRS II and UPDRS III between two group had no statistical difference at the end of 4-8th week,while those scores in observation group were better than those in control group at the end of 12 th week（ P〈0. 05）. Conclusion Behavioral therapy combined with pramipexole has a great effect on the improvement of patients＇ degree of depression and nonmotor symptoms,which has a positive promotion on patients＇ life quality.