妇科消炎方联合硝呋太尔制霉素对老年霉菌性阴道炎C反应蛋白、氧化应激产物的影响及其疗效

Effect of Gynopathic antiphlogistic formula combined with nifuratel and nysfungin on CRP,oxidative stress products and its efficacy in senile colpomycosis

目的探究妇科消炎方联合硝呋太尔制霉素对老年霉菌性阴道炎患者血清C反应蛋白（CRP）、氧化应激产物及临床疗效的影响。方法选取2014年10月-2015年12月在湖州市南浔区中西医结合医院妇产科确诊老年霉菌性阴道炎患者66例,随机分成2组,各33例。对照组予硝呋太尔制霉素阴道软胶囊,联合组在对照组的基础上给予妇科消炎方,6 d为1个疗程,共2个疗程,检测治疗前后血清炎性因子及氧化应激产物水平,并观察临床疗效。结果与治疗前比较,2组血清肿瘤坏死因子α（TNF-α）、CRP、白介素-6（IL-6）、IL-8水平降低（P〈0.05）,超氧化物歧化酶（SOD）、一氧化氮（NO）升高（P〈0.05）,丙二醛（MDA）、内皮素-1（ET-1）降低（P〈0.05）;与对照组比较,联合组血清TNF-α、CRP、IL-6、IL-8水平较低（P〈0.05）,SOD、NO较高（P〈0.05）,MDA、ET-1较低（P〈0.05）。联合组临床疗效显著优于对照组（Z=-2.902,P=0.004）。结论妇科消炎方联合硝呋太尔制霉素对老年霉菌性阴道炎有较好的临床疗效,可有效降低血清炎性因子及氧化应激产物水平,且安全性高。

Objective To explore the effect of Gynopathic antiphlogistic formula combined with nifuratel and nysfungin on serum levels of CRP,oxidative stress products and its efficacy in the treatment of senile colpomycosis. Methods 66 elderly patients of colpomycosis from October 2014 to December 2015 in department of obstetrics and gynecology of Nanxun Integrative Medicine Hospital were selected and randomly divided into two groups,33 cases in each group. Patients in control group received nifuratel and nysfungin soft capsule,the experimental group received Gynopathic antiphlogistic formula on the basis of control group,with two courses,6 days for one course. The serum inflammatory factors,oxidative stress products and clinical curative effect were compared. Results Compared with pre-treatment,the serum TNF α,CRP,IL-6,IL-8 levels decreased（ P〈0. 05）,SOD,NO increased（ P〈0. 05）,MDA,ET-1 decreased（ P〈0. 05）; compared with control group,the serum TNF α,CRP,IL-6,IL-8 level were lower（ P〈0. 05）,SOD,NO were higher（ P〈0. 05）,and MDA,ET-1 were lower（ P〈0. 05）. The clinical efficacy of experimental group was better than that of control group（ Z =-2. 902,P = 0. 004）. Conclusion The Gynopathic antiphlogistic formula combined with nifuratel and nysfungin has a better efficacy in the treatment of senile colpomycosis,which could effectively reduce the serum levels of inflammatory factors,oxidative stress products with high safety.