当归芍药散联合三黄洗剂熏洗对慢性盆腔炎患者TGF-β1、IL-4及IL-10的影响

Effect of Danggui shaoyao powder combined with Sanhuang lotion fumigation on TGF-β1,IL-4 and IL-10 in chronic pelvic inflammatory disease

目的探讨当归芍药散联合三黄洗剂熏洗对慢性盆腔炎患者血转化生长因子β1(TGF-β1)和白介素4(IL-4)、白介素10(IL-10)水平的影响。方法选取慢性盆腔炎患者38例,按照随机数字表法分2组,各19例。对照组予三黄熏洗汤熏蒸坐浴治疗,实验组在对照组基础上予当归芍药散水煎剂治疗,其他治疗相同,10d为1个疗程,治疗2个疗程,治疗前后比较血清TGF-β1和IL-4、IL-10水平及临床疗效。结果实验组治疗总有效率94.74%高于对照组84.21%,差异有统计学意义(P<0.05)。实验组治疗后临床症状评分低于对照组,血清IL-4、TGF-β1水平低于对照组,IL-10水平高于对照组,差异均具有统计学意义(P<0.05)。结论当归芍药散联合三黄洗剂熏洗对慢性盆腔炎降低IL-4、TGF-β1水平,增加IL-10水平,改善炎症状态,效果显著。

Objective To explore the effect of Danggui shaoyao powder combined with Sanhuang lotion fumigation on serum TGF-β1,IL-4 and IL-10 in the treatment of chronic pelvic inflammatory disease. Methods 38 cases with chronic pelvic inflammatory disease were selected and divided into the control group（ 19 cases） and the experiment group（ 19 cases） according to the random number table. The control group were treated with Sanhuang lotion fumigation bath,the experiment group were treated on the basis of the control group with Danggui shaoyao powder,10 days for a course of treatment,a total of two courses of treatment. The serum IL-4,IL-10,TGF-β1 and clinical efficacy were compared before and after treatmentbetweentwo groups. Results The total effective rate of the experiment group was 94. 74%,which was higher than 84. 21% of the control group（ P〈0. 05）. After treatment,the clinical symptom score in experiment group was lower than that in control group,the serum levels of IL-4 and TGF-β1 were lower than those in control group,the serum level of IL-10 was higher than that in control group（ P〈0. 05）. Conclusion Danggui shaoyao powder combined with Sanhuang lotion fumigation could decreases IL-4 and TGF-β1 levels,increase IL-10 level and improve the inflammatory state in the treatment of chronic pelvic inflammatory disease.