黄芪注射液联合β受体阻滞剂对老年心力衰竭患者BNP、IL-1β、IL-6及TNF-α的影响

Effect of astragalus injection combined with beta-adrenoceptor antagonist on BNP,IL-1β,IL-6 and TNF-α levels in senile heart failure patients

目的探讨黄芪注射液联合β受体阻滞剂对老年心力衰竭患者血清脑尿钠肽（BNP）、白细胞介素-1（IL-1β）、白细胞介素-6（IL-6）及肿瘤坏死因子（TNF-α）水平的影响。方法选取2013年4月~2015年4月杭州市余杭区第二人民医院心内科收治的78例心力衰竭患者,随机分为实验组和对照组,各39例,给予纠正电解质与酸碱平衡等常规治疗后,对照组患者采用口服β受体阻滞剂卡维地洛片的治疗方案,实验组患者则在对照组的基础上加用黄芪注射液。2组患者均治疗30 d,比较治疗前后2组患者血清中BNP、IL-1β、IL-6及TNF-α水平。结果治疗后2组患者血清IL-1β、IL-6、TNF-α及BNP水平与治疗前相比均降低（P〈0.05）;与对照组相比,实验组患者血清IL-1β、IL-6,TNF-α及BNP水平较低（P〈0.05）。结论黄芪注射液联合β受体阻滞剂能明显改善老年心力衰竭患者体征,推测其机制可能与降低血清IL-1β、IL-6、TNF-α及BNP水平有关。

Objective To investigate the effect of astragalus injection combined with beta-adrenoceptor antagonist on serum levels of brain natriuretic peptide（ BNP）,interleukin1β（ IL-1β）,IL-6 and tumor necrosis factorα（ TNF-α） in the treatment of elderly patients with heart failure.Methods 78 elderly patients with heart failure from April 2013 to April 2015 in department of cardiology of the second hospital of Yuhang district were selected and divided into control group and experimental group with 39 cases in each group. All patients received correction of the electrolyte and acidbase balance and other conventional treatment. The control group received carvedilol by oral,the experimental group received astragalus injection on the basis of control group,with a course of 30 days. The serum BNP,IL-1β,IL-6 and TNF-α levels pre-and post-treatment in two groups were compared.Results Compared with pre-treatment,the serum IL-1β,IL-6,TNF-α,and BNP levels post-treatment in two groups were lower（ P〈0. 05）. Compared with the control group post-treatment,the IL-1β,IL-6,TNF-α and BNP levels in experimental group were lower（ P〈0. 05）. Conclusion Astragalus injection combined with beta-adrenoceptor antagonist could significantly improve the clinical sign of elderly patients with heart failure,the mechanism may be reducing the serum levels of IL-1β,IL-6,TNF-α and BNP.