生理性海水喷雾洗鼻液对轻度间歇性变态反应性鼻炎患儿的效果观察

Efficacy of sterimar physiological sea water spray nasal spray on mild intermittent allergic rhinitis children

目的观察生理性海水喷雾洗鼻液对轻度间歇性变态反应性鼻炎（allergic rhinintis,AR）患儿的效果。方法选取临海市第一人民医院耳鼻咽喉科2014年3月~2015年3月收治疗的轻度间歇性AR患儿共81例,所有病例按双盲、随机数字表法分为观察组40例和对照组41例。对照组给予常规氯雷他定治疗,观察组在对照组的基础上给予生理性海水喷雾洗鼻液进行治疗,分析2组患儿治疗前后AR症状、体征评分、纤毛传输速率、临床疗效对比情况。结果观察组患儿治疗后的AR症状、体征评分均明显低于对照组（t=12.908、t=11.340;P〈0.05）。观察组纤毛传输速率提高显著大于对照组（t=4.119;P〈0.05）。观察组治疗后总有效率明显高于对照组（97.50%vs.80.49%;χ2=5.933,P〈0.05）。结论生理性海水喷雾洗鼻液对轻度间歇性AR患儿临床治疗效果确切,可有效缓解相关症状。

Objective To observe the effect of sterimar physiological sea water spray nasal spray on children with mild intermittent allergic rhinitis（ AR）. Methods 81 cases with mild intermittent AR from March 2014 to March 2015. All the cases were divided into observation group（ n = 40） and control group（ n = 41） according to the double blind and random number table method. The control group were given conventional loratadine treatment,observation group on the basis of the control group given sterimar physiological sea water spray nasal spray treatment. The symptoms of allergic rhinitis,signs score,mucociliary transport rate and clinical curative effect between two groups pre-and post-treatment were analysed and compared. Results After treatment,the symptoms of allergic rhinitis,signs score in observation group were significantly lower than those in control group（ t = 12. 908,t = 11. 340;P〈0. 05）. The mucociliary transport rate in observation group was significantly higher than that in control group（ t = 4. 119; P〈0. 05）. The total effective rate of observation group was significantly higher than that of control group（ 97. 50% vs. 80. 49%; χ2= 5. 933,P〈0. 05）. Conclusion The clinical treatment effect of sterimar physiological sea water spray nasal spray could effectively alleviate the symptoms in the treatment of children with mild intermittent AR,which has an accurate efficacy.