1990年与2013年中国人群白血病疾病负担分析

Disease burden of leukemia in the Chinese population, in 1990 and 2013

目的分析1990年与2013年中国人群白血病的疾病负担及其变化情况。方法利用中国分省疾病负担研究结果，分析和比较1990年与2013年全国白血病的发病、死亡情况及伤残调整寿命年（DALY）、过早死亡损失寿命年（YLL）和伤残损失寿命年（YLD）。描述2013年各省份白血病标化死亡率及与1990年相比白血病标化死亡率的变化情况。结果2013年中国人群白血病标化发病率为6．70／10万，标化死亡率为4．05／10万，较1990年分别降低8．84％和36．22％。2013年白血病标化DALY率、标化YLL率分别为174．58／10万和170．42／10万，较1990年分别下降44．68％和45．32％。2013年白血病标化YLD率为4．16／10万，与1990年相比，升高6．94％。年龄别数据显示，2013年，35岁以下人群因白血病死亡人数占因癌症死亡总数的比例高于10％，5岁以下儿童白血病DALY率最高，为317．61／10万。2013年与1990年相比，各省份人群白血病标化死亡率均出现下降，2013年白血病标化死亡率最高的前3个省份为新疆（4．72／10万）、宁夏（4．56／10万）和福建（4．50／10万）。结论中国人群白血病标化发病率、死亡率、DALY率和YLL率下降，但YLD率升高，儿童、青少年因白血病死亡占因癌症死亡的构成比较高。各省份白血病标化死亡率均下降，但仍存在差异。

Objective Toanalyze the disease burden of-leukemia in the Chinese population, in 1990 and 2013. Methods Data related to province-specific disease burden in China was used to analyze and compare related parameters as incidence, mortality, the disability-adjusted life years （DALY）, years of life lost due to premature mortality （YLL） and years lived with disability （YLD） on leukemia in China in 1990 and 2013. Standardized mortality rates of leukemia in each province in 2013 and the changes since 1990, were described. Results In 2013, the standardized incidence and mortality rates of leukemia in China were 6.70/100 000 and 4.05/100 000, with reduction of 8.84% and 36.22% when compared with those in 1990, respectively. The standardized DALY rate and YLL rate appeared as 174.58/100 000 and 170.42/100 000 in 2013, with 44.68% and 45.32% reduction, respectively, when compared with the figures in 1990. The standardized YLD rate of leukemia in 2013 was 4.16/100 000, with an 6.94% increase, comparing with that in 1990. Age-specific data showed that the proportion of people who died from leukemia among those who died from all the cancers was more than 10% in people under 35 years old. DALY rate of leukemia was highest among children aged 5 years old and under, which appeared as 317.61/100 000. Compared with those in 1990, the standardized mortality of leukemia appeared decreasing in all the provinces in 2013. The top three provinces with the highest standardized mortality of leukemia in 2013 were Xinjiang （4.72/100 000）, Ningxia （4.56/100 000） and Fujian （4.50/100 000）. Conclusions Although the standardized incidence rate, mortality rate, DALY rate and YLL rate due to leukemia decreased, YLD rate due to leukemia increased. Proportions of children and adolescents who died from leukemia remained high. Although the standardized mortalities of leukemia decreased in all the provinces, the differences among them still remained.