细胞糖代谢方式改变与肿瘤转移的相关性

Alteration of Cell Glycometabolism Pathway and Tumor Metastasis

肿瘤转移是引起肿瘤相关死亡的主要原因,肿瘤细胞的代谢异常在肿瘤转移中扮演重要角色。肿瘤的糖代谢以"Warburg效应"为显著特征,即细胞在有氧条件下也以糖酵解为主要糖代谢途径提供能量。而这种现象在转移性肿瘤细胞中更为突出,表现为葡萄糖的大量摄取、高糖酵解速率和核酸合成速率等,这为肿瘤细胞的快速生长和增殖提供了重要的能量和物质基础。对于肿瘤转移过程中相关代谢改变的研究,将为最终揭示肿瘤转移的机制打下基础。本文综述肿瘤细胞糖代谢中糖酵解、线粒体有氧代谢及磷酸戊糖途径中的变化与肿瘤转移发生的相关性,其结果为进一步从调控肿瘤代谢角度发现新的肿瘤转移控制手段提供了启示。

Tumor metastasis is the main cause of cancer-related death. Abnormal glucose metabolism of tumor cells plays a key role in tumor metastasis. One of the features for glucose metabolism of cancer cells is ＂ Warburg effect＂,which means tumor cells mainly produce energy by glycolysis even if oxygene is abundant. It has been proved that enhanced Warburg effect was found in metastatic cancer cells.Metastatic cancer cells have faster growth rate and high proliferation ability with enormous glucose flux and high rate of glycolysis and nucleotide biosynthesis. The research focus on glucose metabolism of metastatic tumor cells will shed light on better understanding the mechanisms for tumor metastasis. Here,we reviewed the most recent research progress on the alteration of glucose metabolism in metastatic tumor cells,such as glycolysis,aerobic metabolism of mitochondria and pentose phosphate pathway（ PPP）.These results suggested that understanding tumor metabolism regulation will help us to find new strategies in controlling tumor metastasis.