血管活性因子对肉鸡腹水综合征形成及发展的影响

Effect of Vascular Active Factors on Formation and Development of Ascites Syndrome in Broiler

肺动脉压升高是肉鸡肺动脉高压综合征发病过程的中心环节。研究表明血管活性物质在体内的失衡是诱发肉鸡肺动脉压变化的主要因素,并在肉鸡腹水综合征发生发展过程中发挥着重要的作用。文章论述了一氧化氮、内皮素、血管紧张素Ⅱ、5-羟色胺、缺氧诱导因子以及心钠素等血管活性因子对肉鸡肺动脉高压形成及发展的影响,探讨血管活性因子在肉鸡腹水综合征发病过程中的作用,为建立该病的诊断和防控方法提供理论依据。

The increase of pulmonary artery pressure（PAP）is considered to be the central part of pathogenic progress of pulmonary hypertension syndrome（PHS）. Recent studies show the main factor that induced the alteration of PAP is the imbalance of vasoactive substance in the body,which plays an important role in the development of ascites syndrome（AS）. The effects of vascular active factors including nitric oxide（NO）,endothelin（ET）,angiotensin Ⅱ（AT）,5-hydroxytryptamine（5-HT）,hypoxia-inducible factor（HIF）and atrial natriuretic factor（ANF）on formation and development of AS were described in this paper,which used to investigate the role of vascular active factor in the pathogenic progress of AS,as well as provide theory basis to develop the diagnostic and control methods.