柳氮磺胺吡啶对神经胶质瘤致癫痫的疗效研究

Efficaey of sulfasalazine in the treatment of epilepsy caused by gliomas

目的探究柳氮磺胺吡啶(SAS)治疗神经胶质瘤导致的癫痫的疗效。方法选择2006年3月至2013年12月就诊南方医科大学珠江医院神经外科的胶质瘤导致癫痫的患者,予以SAS控制癫痫的发作,分别计算50%、75%有效率及发作完全控制率来评估SAS治疗的疗效,同时根据癫痫发作结局的评分标准对患者进行评分,来分析SAS对不同类型的癫痫的疗效。结果患者给予SAS治疗后1、2、3个月时每个月发作频率平均减少率分别为54.32%、61.71%、75.74%。每个月发作频率平均减少率在治疗后较治疗前差异有统计学意义(P<0.01)。治疗后50%有效率、75%有效率、完全控制率不同时间点与治疗前比较,差异有统计学意义(F=20.007,P<0.01)。治疗3个月后不同类型癫痫患者中单纯部分性发作(SPS)和复杂部分性发作(CPS)类型癫痫的完全控制和发作改善率均为100.00%,而部分性发作继发全面性强直阵挛发作(SGTCS)和特发性或隐源性全面性发作(GS)分别为84.62%和75.00%,它们完全控制和发作改善率差异无统计学意义(P>0.05)。结论 SAS能够有效控制胶质瘤导致的癫痫发作,且对各种类型的癫痫均有效。

Objective To explore the efficacy of sulfasalazine for treatment for epilepsy induced by gliomas .Methods The patients with epilepsy caused by gliomas in neurosurgery department were recruited from March 2006 to December 2013 .Epilepsy was controlled with sulfasalazine .The efficacy of sulfasalazine for treatment for epilepsy induced by glioma were analyzed to calcu-late the 50% response rate ,75% response rate and seizure-free rate .Meanwhile the outcomes scores of therapy of sulfasalazine for varieties types of epilepsy were evaluated ,according to the end result of scoring criteria in epileptic seizures .Results A total of 31 patients were controlled with sulfasalazine .The average reduction rate of seizure frequency per month was 54 .32% ,61 .71% , 75 .74% after three months of treatment .The differences of average reduction rate of seizure frequency before and after the treat -ment have an evident statistic significance （P〈0 .01） .The 50% response rate ,75% response rate and seizure-free rate per month af-ter treatment with sulfasalazine have significant higher than those before treatment （F= 20 .007 ,P〈0 .01） .After 3 month of thera-py ,four different types of epilepsy was 100 .00% ,100 .00% ,84 .62% and 75 .00% in improvement rate added complete control rate .Those have no statistical difference（P〉0 .05） .Conclusion Sulfasalazine can effectively control seizures ,and both effective va-rious types of epileptic .