灵孢多糖注射液联合西酞普兰治疗抑郁症的疗效和安全性研究

The efficacy and safety of Ganoderma Lucidum Polysaccharides in the treatment of depression

目的：观察灵孢多糖注射液辅助治疗抑郁症的疗效和安全性。方法入选2010年10月～2013年3月于我院门诊确诊的抑郁症患者80例，所有病例均符合汉密顿抑郁量表（HAMD）17项评分（≥17分），随机分为试验组（灵孢多糖注射液＋西酞普兰）和对照组（西酞普兰组）每组各40例。西酞普兰20mg/d口服，灵孢多糖注射液2ml/d肌注＋西酞普兰20mg/d口服，两组患者疗程均为8周。在治疗前及治疗第4周和第8周，采用HAMD评分，评定疗效。结果治疗4周后，试验组HAMD评分降至（7.13±2.15），与基线期（22.13±5.22）相比，差异有显著性统计学意义（P〈0.01），与对照组相比，差异有显著性统计学意义（P〈0.01）。治疗8周后，试验组减分率（%）（79.93±20.43）优于对照组（70.99±19.26），差异有统计学意义（P〈0.05）。结论灵孢多糖注射液具有辅助治疗抑郁症的作用。

Objective To evaluate the efficacy and safety of Ganoderma Lucidum Polysaccharides Injection in the treatment of patients with depression.Method During October 2010 and March 2013, in the hospital outpatient service, 80 depression patients were screened with Hamilton depression scale-17 （ HAMD-17 ） （≥17）and randomly divided into experiment group （Ganoderma Lucidum Polysaccharides combined with Citalopram） and control group （Citalopram）, 40 cases in each group . Ganoderma Lucidum Polysaccharides, 2ml/d, i.m. and Citalopram 20mg/d,p.o. Period of treatment are 8 weeks in both groups. The efficacy were evaluated by Hamilton Depression Scale-17 （HAMD-17）.Results Four weeks after treatment, the experiment group could reduce the HAMD -17 score of the patients to（7.13±2.15）, lower than the baseline period （22.13±5.22） （P〈0.01）, and lower than control group with statistical significance （P〈0.01）. After 8 weeks treatment, score-reducing rate （79.93±20.43）% in the experiment group decreased obviously,and lower than control group （70.99±19.26）%, with statistical significance （P〈0.05）.Conclusion Ganoderma lucidum polysaccharides have assisting effect on depression.