摘要
目的探讨创伤后应激障碍(PTSD)患者的执行功能损害特点及静息态下脑区局部一致性变化情况。方法纳入20例PTSD患者及19例年龄、性别及受教育程度均匹配的健康对照组进行静息状态下的功能磁共振成像扫描,采用局部一致性(ReHo)的分析方法计算两组静息态下全脑局部一致性情况。结果 PTSD患者在右侧额中回、额下回、颞上回、颞中回及双侧扣带回表现出明显增高的局部一致性(P < 0.05)。结论 PTSD患者的大脑活动异常主要分布在认知、记忆及情感相关脑区,这些异常的自发神经元活动可能是PTSD患者认知缺陷的神经基础。
Objective To investigate the executive dysfunctional characteristics and regional homogeneity（Re Ho）changes of the resting state in the brain region with posttraumatic stress disorder（PTSD）patients.Methods The resting state f MRI were performed in 20 PTSD patients and 19 age,education,and sex-matched normal healthy subjects.The method Re Ho was used to analyze the brain region changes with PTSD,then Re Ho was compared between the PTSD and normal control groups.Results Compared to the control group,the PTSD group showed significantly increased Re Ho values inright middle frontal gyrus,inferior frontal gyrus,superior temporal gyrus,middle temporal gyrus and bilateral cingulate gyrus（P 〈 0.05）.Conclusions The results indicated the ALFF values in some brain regions in the PTSD group were abnormal in the resting state.This abnormality mainly distributed in cognition and motor related brain regions,which can reflex neural basis of cognitive deficits in PTSD patients though these abnormal spontaneous neuronal activity.
出处
《功能与分子医学影像学（电子版）》
2016年第1期4-8,共5页
Functional and Molecular Medical Imaging(Electronic Edition)
基金
广东省科技计划项目(2012A030400019)
国家自然科学基金项目(11402057)
关键词
急性创伤后应激障碍
功能磁共振成像
静息态
脑区局部一致性
regional homogeneity
resting state
functional magnetic resonance imaging
post-traumatic stress disorder
