球囊扩张辅助CDT治疗产后下肢DVT的临床研究

Clinical study of balloon dilatating auxiliary CDT in treatment of postpartum lower extremity DVT

目的探讨囊扩张辅助经导管直接溶栓（CDT）治疗产后下肢深静脉血栓形成（DVT）的临床效果。方法选取2013年7月-2015年1月间收治的产后下肢（DVT患者76例为研究对象,根据入院时间顺序随机分为观察组及对照组,各38例。对照组接受CDT治疗,观察组接受球囊扩张辅助CDT治疗。比较两组的临床症状缓解时间、主要治疗指标、凝血功能、临床疗效。结果观察组的总有效率（97.37%）明显高于对照组（81.58%）,疼痛、下肢肿胀、行动受限等临床症状缓解时间明显短于对照组,尿激酶用量、溶栓时间、患/健肢周径差、静脉通畅度评分均明显低于对照组,凝血酶原时间（PT）、活化部分凝血酶时间（APTT）、凝血酶时间（TT）均明显高于对照组,纤维蛋白原（FG）明显低于对照组,差异均有统计学意义（P〈0.05）。结论球囊扩张辅助CDT治疗有助于缓解产后下肢深静脉血栓形成患者临床症状,改善凝血功能,提高治疗效果。

Objective To explore the clinical effects of balloon dilatating auxiliary CDT in treatment of postpartum lower extremity DVT.Methods A total of 76 patients who had been suffering postpartum lower extremity DVT and had been admitted to our hospital from July 2013 to January 2015 were selected and divided into an observation group and a control group（n =38,respectively） according to the admission time.The control group received CDT,while the observation group received balloon dilatating auxiliary CDT.The relief time for clinical symptoms,key treatment indicators,coagulation function and clinical effect of the two groups were compared.Results The total effective rate（97.37%） of the observation group was much higher than that of the control group（81.58%）; the relief time for clinical symptoms,such as pain,lower extremity swelling and limited movement of the observation group was shorter than that of the control group; dosage of urokinase,thrombolysis time,diseased/healthy limb cross-section diameter difference and venous patency score were lower than those of the control group; the PT,APTT and TT were longer than those of the control group; the FG was much lower than that of the control group（P〈0.05）.Conclusion Balloon dilatating auxiliary CDT can relieve the clinical symptoms of postpartum lower extremity DVT,improve coagulation function and enhance treatment effect.