排毒尪痹汤治疗类风湿性关节炎活动期随机平行对照研究

A Randomized Parallel Controlled Study of Paidu Wangbi Decoction for the Treatment of Rheumatoid Arthritis in Active Stage

目的观察排毒尪痹汤治疗类风湿性关节炎有效性及安全性。方法使用随机平行对照方法将200例住院及门诊患者按随机数字表法分为两组。对照组100例口服吲哚美辛肠溶片25 mg/次,1次/d,甲氨蝶呤片7.5 mg/次1,次/周。治疗组100例,排毒尪痹汤煎服200 m L/次,2次/d。连续治疗4周为1疗程。2疗程后观测临床症状、晨僵时间、关节痛及压痛数、关节肿胀、血沉、类风湿因子滴度、握力、步行时间、不良反应。判定疗效。结果治疗组临床总有效率94%。对照组总有效率82%。治疗组疗效优于对照组(P<0.05)观察指标均有改善,治疗组优于对照组(P<0.05,P<0.01)。结论排毒尪痹汤治疗类风湿性效果显著,值得推广。

Objective： To observe the curative effect and safety of Paidu Wangbi Decoction for the treatment of rheumatoid arthritis patients. Methods： By using a randomized parallel controlled method, 200 inpatients and outpatients were randomly divided into two groups, 100 cases per group. The control group was given oral indomethacin enteric - coated tablets 25 mg each time, once daily, and methotrexate tablets 7.5 mg each time, once weekly while the treatment group was given Paidu Wangbi Decoction 200 mL each time, twice daily. Continuous four weeks was a course of treatment. After 2 - course treatment, clinical symptoms, duration of morning stiffness, joint pain, tenderness count, joint swelling, erythrocyte sedimentation rate, rheumatoid factor titers, grip strength, walking time and adverse reactions were observed and the curative effect was judged. Results： The total effective rate of the treatment group was 94% while that of the control group was 82%. The treatment group was better than the control group （P 〈 0. 05 ）. The observation indicators improved and the treatment group was better than the control group （P 〈 0. 05, P 〈 0.01 ）. Conclusion： Paidu Wangbi Decoction has a significant effect on the treatment of rheumatoid arthritis, worthy of wide application.