武汉地区94例青中年慢性咳嗽临床分析

Clinical Analysis of 94 Young and Middle-aged Patients with Chronic Cough in Wuhan Area

【目的】分析了解武汉地区青中年患者慢性咳嗽的病因构成并探讨有效的治疗方法。【方法】收集2013年1月至2014年12月在本院就诊的青中年慢性咳嗽患者94例，遵循我国咳嗽指南慢性咳嗽诊断流程进行相应的检查，根据检查结果和治疗后反应，确定病因诊断，分析特异性治疗的临床疗效。【结果】94例慢性咳嗽患者明确诊断咳嗽病因91例（96．8％）。单一病因咳嗽者86例（91．5％），二重病因5例（5．3％）。慢性咳嗽病因分布依次为：咳嗽变异性哮喘30例次（30．3％）、上气道咳嗽综合征23例次（23．2％）、嗜酸粒细胞性支气管炎14例次（14．1％）、胃食管反流性咳嗽9例次（9．1％）、变应性咳嗽5例次（5．1％）、感染后咳嗽4例次（4．0％）、支气管结核4例次（4．0％）、其他病因7例次（7．1％）、病因未明3例次（3．0％）。经特异性治疗后，94例患者临床控制73例（77．7％），显效13例（13．8％），好转4例（4．3％），总有效率95．7％。【结论】武汉地区青中年患者慢性咳嗽主要病因构成为咳嗽变异性哮喘、上气道咳嗽综合征、嗜酸粒细胞性支气管炎、胃食管反流性咳嗽、变应性咳嗽。对慢性咳嗽明确诊断后，针对性治疗可取得良好的治疗效果。

[Objective]To analyze the causes of chronic cough in the young and middle aged patients in Wuhan area and to explore the effective treatment methods.[Methods]Ninety-four young and middle-aged pa- tients with chronic cough in our hospitals were selected from January 2013 to December 2014. The causes were investigated by the well-established protocol according to The Chinese Respiratory Society Guidelines for Man- agement of Cough. Following the guidelines for the diagnosis of chronic cough in our country, the clinical effi- cacy of specific treatment was analyzed and the cause diagnosis determined according to the examination results and treatment reaction.[Results] Ninety-one cases of chronic cough were diagnosed in 94 cases （96.8%）. Sin- gle cause cough covered 86 cases （91.5 %）, double causes took 5 cases （5.3 %）. Cause distribution of chronic cough was as follows.. 30 cases （30.3%） for cough variant asthma , 23 cases （23.2%） for upper airway cough syndrome, 14 cases （14.1%） for eosinophil bronchitis , 9 cases（9.1%） for gastroesophageal reflux , 5 cases （5.1%） for allergic cough, 4 cases （4 %） for post-infection, 4 cases （4.0 %） for bronchial tuberculosis, 7 cases （7.1 % ） for other causes and etiology of 3 cases （3.0 % ） unknown. After specific treatment, 73 cases （77.7 % ） out of 94 were clinically controlled , 13 cases （13.8%） marked effective , 4 cases （4.3%） improved, the total effective rate was 95.7%.[Conclusion]The main causes of chronic cough in young and middle aged patients in Wuhan area are co＇ugh variant asthma, upper airway cough syndrome, eosinophilic bronchitis, gastroesophage- al reflux cough and allergic cough. After definite diagnosis of chronic cough, a good therapeutic effect can be expected to achieve.