妊娠期肾病综合征临床特点回顾性分析

Retrospective analysis on the clinical characteristics of nephrotic syndrome during pregnancy

目的分析探讨妊娠期肾病综合征的临床特点,为临床诊治提供参考。方法回顾性分析2011~2014年在北京煤炭总医院住院的69例重度子痫前期患者的临床资料,22例妊娠期肾病综合征患者为肾病组,47例重度子痫前期无合并肾病综合征患者为对照组,比较两组患者血压、低蛋白血症情况、肾功能指标和围生结局。结果肾病组与对照组血压比较差异无统计学意义(P>0.05),肾病组的肾功能损害较严重,其血清总蛋白、白蛋白低于对照组,尿素氮、肌酐、早产率、新生儿并发症发生率、围产儿死亡率均比对照组高,差异有统计学意义(P<0.05)。结论妊娠期肾病综合征具有病情较重、进展快等特点,为保证母婴安全并减少并发症,可根据具体情况适时终止妊娠。

Objective To analyze and explore the clinical characteristics of nephrotic syndrome during pregnancy （NSP） to provide reference for clinical diagnosis and treatment. Methods Analyzed the data of 69 patients with severe preeclampsia who hospitalized in Coal hospital of Be^jing from January 2011 to December 2014 retrospectively, in which 22 cases with NSP were selected as kidney disease group, the other 47 cases without NSP were selected as control group. Blood pressure index, hypoalbuminemia status, renal function and perinatal outcomes of two groups were compared. Results Blood pressure of two groups had no significant difference（P 〉 0. 05 ）, kidney disease group had severer renal function damage, total serum protein and albumin of kidney disease group were lower than those of control group, urea nitrogen, creatinine, premature delivery rate, occurrence rate of newborn complication, mortality rate of perinatal infant of kidney disease group were higher than those of control group, the differences were statistical significant（P 〈 0. 05 ）. Conclusion NSP has features of heavy and progressing quickly. In order to ensure the safety of maternal and fetus and reduce the complications, it＇ s able to terminate the pregnancy timely according to the concrete conditions.