复方三芪丹胶囊对糖尿病大鼠糖代谢的影响及其作用机制研究

Effects of Sanqidan Capsules on Glucose Metabolism and Its Mechanism of Action on Diabetic Rats

目的:观察复方三芪丹胶囊对糖尿病大鼠糖代谢的作用及其作用机制。方法:通过链脲佐菌素制备大鼠高血糖模型,测定给药后糖尿病大鼠空腹血糖(FBG)、糖耐量、血清胰岛素(FINS)、肝糖原含量及SOD、MDA、TNF-a水平,评价复方三芪丹胶囊的效果。结果:复方三芪丹胶囊明显降低糖尿病模型大鼠FBG,改善模型大鼠糖耐量,升高FINS及肝糖原含量,提高SOD活性,降低MDA、TNF-a水平。结论:复方三芪丹胶囊通过调整糖代谢降低糖尿病大鼠血糖水平。

Objective： To study the therapeutic effects of Sanqidan Capsules and its mechanism of action on type 2 diabetic rats. Methods： Diabetic rats were induced by injecting streptozotocin. FBG,glucose tolerance,FINS,SOD,MDA and TNF-α and liver glycogen store were measured after taking Sanqidan Capsules 4 weeks and the hypoglycemic effect of Sanqidan Capsules was evaluated. Results： Sanqidan Capsules significantly reduced FBG and glucose tolerance,elevated liver glycogen store and FINS,increased SOD activity and lowered MDA and TNF-α levels. Conclusion： Sanqidan Capsules lower the blood sugar levels in diabetic rats by adjusting the glucose metabolism.