摘要
目的:探讨在规范化治疗高血压的基础上,加用麝香通心滴丸对血浆肾素-血管紧张素-醛固酮系统的影响。方法:60例高血压患者随机分为两组,对照组30例及麝香通心滴丸治疗组30例。对照组采用"氨氯地平加/或比索洛尔"等治疗,治疗组在对照组治疗的基础上加用"麝香通心滴丸(每天3次,每次2粒)",观察治疗周期为6个月。所有患者在治疗开始及治疗结束时,行动态血压检测血压及血浆肾素、血管紧张素II、醛固酮浓度测定。结果:与对照组相比,麝香通心滴丸治疗组血浆肾素、血管紧张素II、醛固酮浓度水平明显降低,差异具有统计学意义(P<0.05或P<0.01),治疗组的24 h舒张压、白天舒张压水平较对照组下降明显,差异有统计学意义(P<0.05)。结论:麝香通心滴丸可以抑制高血压患者的血浆肾素、血管紧张素II及醛固酮系统。
Objective: To investigate the effect of Shexiang Tongxin Dropping Pill( STDP) on renin-angiotensin-aldosterone system( RAAS) in essential hypertension( EH). Methods: Sixty patients with EH were randomly divided into two groups: : control group( n = 30) and STDP treatment group( n = 30). Control group was treated with Amlodipine and / or Bisoprol and STDP treatment group given STDP( 2 pills,tid) in addition to western medicine. After 6 months' treatment,levels of serum renin,angiotensin,aldosterone and 24-hour ambulatory blood pressure were observed with holter.Results: At the end of this study,STDP treatment group manifested with significantly decreased levels of serum renin,angiotensin,aldosterone,24-DBP and d-DBP( P〈0. 05 or P〈0. 01). Conclution: STDP may control renin-angiotensin-aldosterone system.
出处
《中华中医药学刊》
CAS
北大核心
2016年第6期1351-1353,共3页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省中西医结合学会临床药学科研专项基金项目(2013LYSX001)
关键词
高血压
肾素、血管紧张素及醛固酮系统
麝香通心滴丸
essential hypertension
renin-angiotensin-aldosterone system
Shexiang Tongxin Dropping Pill