麝香通心滴丸对高血压患者肾素-血管紧张素-醛固酮系统的影响

Effect of Shexiang Tongxin Dropping Pill on Renin-Angiotensin-Aldosterone System in Essential Hypertension

目的:探讨在规范化治疗高血压的基础上,加用麝香通心滴丸对血浆肾素-血管紧张素-醛固酮系统的影响。方法:60例高血压患者随机分为两组,对照组30例及麝香通心滴丸治疗组30例。对照组采用"氨氯地平加/或比索洛尔"等治疗,治疗组在对照组治疗的基础上加用"麝香通心滴丸(每天3次,每次2粒)",观察治疗周期为6个月。所有患者在治疗开始及治疗结束时,行动态血压检测血压及血浆肾素、血管紧张素II、醛固酮浓度测定。结果:与对照组相比,麝香通心滴丸治疗组血浆肾素、血管紧张素II、醛固酮浓度水平明显降低,差异具有统计学意义(P<0.05或P<0.01),治疗组的24 h舒张压、白天舒张压水平较对照组下降明显,差异有统计学意义(P<0.05)。结论:麝香通心滴丸可以抑制高血压患者的血浆肾素、血管紧张素II及醛固酮系统。

Objective： To investigate the effect of Shexiang Tongxin Dropping Pill（ STDP） on renin-angiotensin-aldosterone system（ RAAS） in essential hypertension（ EH）. Methods： Sixty patients with EH were randomly divided into two groups： ： control group（ n = 30） and STDP treatment group（ n = 30）. Control group was treated with Amlodipine and / or Bisoprol and STDP treatment group given STDP（ 2 pills,tid） in addition to western medicine. After 6 months＇ treatment,levels of serum renin,angiotensin,aldosterone and 24-hour ambulatory blood pressure were observed with holter.Results： At the end of this study,STDP treatment group manifested with significantly decreased levels of serum renin,angiotensin,aldosterone,24-DBP and d-DBP（ P〈0. 05 or P〈0. 01）. Conclution： STDP may control renin-angiotensin-aldosterone system.