“疏肝清火”法治疗桥本甲状腺炎临床观察

Clinical Observation on Soothing Liver and Clearing Fire Method in Treatment of Hashimoto's Thyroiditis

目的：探讨＂疏肝清火＂法中药对桥本甲状腺炎（HT）临床疗效。方法：将62例HT患者随机分为治疗组30例和对照组32例。两组有甲状腺功能亢进、甲状腺功能减退者分别予甲巯咪唑片10 mg/d、左旋甲状腺素片25～50μg/d控制甲状腺功能,稳定2周后,治疗组在此基础上加用＂疏肝清火＂法中药治疗,疗程6个月。结果：中医临床证候两组均有改善,除口干渴、健忘外组间比较差异均有有统计学意义（P〈0.05,P〈0.01）。治疗组中医证候疗效为90%（27/30）,对照组为59.375%（19/32）,两组比较差异有统计学意义（P〈0.01）。两组比较差异有统计学意义（P〈0.05）。治疗组治疗后血清TGAb、TPOAb水平较治疗前下降（P〈0.05）,对照组血清TPOAb、TGAb水平虽较前有所下降但无统计意义（P〉0.05）,两组比较差异有统计学意义（P〈0.01）。结论：使用＂疏肝清火＂法中药治疗HT可缓解症状,并能有效降低甲状腺自身免疫性抗体指标。

Objectives： To investigate the clinical effect of the soothing liver and clearing fire method in the treatment of Hashimoto＇s thyroiditis（ HT）. Methods： 62 cases of HT patients were randomly divided into 2 groups. The treatment group had 30 patients and the control group 32 patients. In these 2 groups,the patients with hyperthyroidism were given methimazole tablets 10 mg / d and those with hypothyroidism took L-thyroxine tablets 25 ～ 50 μg / d to control the thyroid function. After two weeks,the treatment group used the soothing liver and clearing fire method of traditional Chinese medicine on the basis of the original treatment for six months. Results： The TCM clinical syndromes were improved in both two groups. Except the syndromes of thirsty and forgetfulness,the difference between 2 groups were statistically significant in TCM clinical syndromes（ P〈0. 05,P〈0. 01）. The clinical effect of the TCM syndrome in treatment group was 90%（ 27 /30） while the control group＇s was 59. 375%（ 19 /32） and the difference between 2 groups was statistical significant（ P〈0. 01）. The difference between the two groups was statistical significant（ P〈0. 05）. The levels of the serum TGAb and TPOAb were decreased after treatment in treatment group（ P〈0. 05） and those were also decreased after treatment in control group,but it was not statistically significant（ P〉0. 05）. The difference between 2 groups was statistically significant（ P〈0. 01）. Results： The syndromes can be relieved with the method of soothing liver and clearing fire in HT,and the thyroid autoantibodies indicators can be effectively reduced.