参芪降糖颗粒、银杏叶胶囊联合甲钴胺及α-硫辛酸治疗糖尿病周围神经病变的临床疗效

Shengqi Jiangtang Capsule and Ginkgo Leaf Capsule Combined with Mecobalamin and Alpha Lipoic Acid in Treatment of Diabetic Peripheral Neuropathy

目的:对比分析参芪降糖颗粒、银杏叶胶囊联合甲钴胺及α-硫辛酸治疗糖尿病周围神经病变的临床疗效。方法:研究对象来源于医院收治的116例糖尿病周围神经病变患者,根据掷骰子法将患者随机分为两组,每组58例。实验组患者采用参芪降糖颗粒、银杏叶胶囊联合甲钴胺及α-硫辛酸配合治疗,对照组患者使用甲钴胺及α-硫辛酸治疗。对比两组患者的不良反应发生率、周围神经平均传导速度及治疗后总有效率。结果:实验组患者的不良反应发生率(15.52%)明显优于对照组患者的(39.66%);实验组患者周围神经平均传导速度(60.25±0.26)m/s明显优于对照组的(50.96±0.68)m/s;实验组患者总有效率(98.27%)明显优于对照组的(91.38%),其差异在统计学上有意义(P<0.05)。结论:通过参芪降糖颗粒、银杏叶胶囊联合甲钴胺及α-硫辛酸联合治疗糖尿病周围神经病变后,能有效地降低不良反应发生概率、周围神经平均传导速度及治疗总有效率均有明显的提高,短期临床效果较好,但远期的临床效果仍然需要通过延长随访时间和加大样本量来进行证实。

Objective： To compare and analyze the clinical curative effect of Shengqi Jiangtang Granule and Gingko Leaf Capsule combined with mecobalamin and alpha lipoic acid in the treatment of the patients with diabetic peripheral neuropathy. Methods： A total of 116 patients with diabetic peripheral neuropathy were randomly divided into two groups,58 cases in each group. The patients in the experimental group were given Shengqi Jiangtang Granule and Gingko Leaf Capsule combined with mecobalamin and alpha lipoic acid treatment and those in the control group treated with mecobalamin and alpha lipoic acid treatment. The incidence of adverse reactions,peripheral nerve conduction velocity and total effective rate were compared between two groups. Results： The incidence rate of adverse reactions in the experimental group（ 15. 52%） was significantly better than that in the control group（ 39. 66%）. The average conduction velocity of peripheral nerve in the experimental group（ 60. 25 0. 26） m / second was significantly better than the control group ＇s（ 50. 96 0. 68） m/second. The total effective rate in the experimental group（ 98. 27%） was significantly better than the control group＇s（ 91. 38%） and the difference was statistically significant（ P〈0. 05）. Conclusion： Shengqi Jiangtang Granule and Gingko Leaf Capsule combined with mecobalamin and alpha lipoic acid in the treatment of the patients with diabetic peripheral neuropathy can effectively reduce the adverse reactions,significantly improve the mean nerve conduction velocity and the total effective rate. The short-term clinical effect is good but long-term clinical effect still need to be confirmed through prolonged follow-up time and increased sample.