崩漏停对药物流产大鼠子宫出血模型的影响

Effect of Benglouting on Uterine Bleeding of Medical Abortion Rats

目的:采用流产大鼠子宫出血模型研究崩漏停治疗在体子宫出血症状。方法:采用早孕大鼠灌服米非司酮和米索前列醇造成阴道出血模型,观察崩漏停对该模型子宫出血量的影响,同时观察大鼠的血浆凝血指标、血清雌二醇和孕酮水平变化,子宫和卵巢重量及组织学形态变化。结果:崩漏停对药物流产大鼠有促进凝血和减少子宫出血的作用,高剂量可提高血清雌二醇和孕酮水平。子宫和卵巢组织病理学检查,高剂量组的卵巢功能恢复最好,药物流产子宫内膜修复评分值高剂量组最高,但各组间没有明显差异。结论:崩漏停可减少早孕大鼠药物流产模型的子宫出血量,并有助于卵巢和子宫内膜修复。

Objective： Uterine bleeding model rats were carried out to study Benglouting on uterine bleeding. Methods：Mifepristone and misoprostol were given to early-pregnancy rats orally to cause vaginal hemorrhage model in rats. The effects of Benglouting were observed by the change of uterine bleeding quantity,plasma coagulation index,serum estradiol and progesterone levels. The weight and histological change of uterus and ovary were observed as well. Results： Benglouting could promote coagulation and reduce uterine bleeding quantity in uterine bleeding model rats. High dose can improve the levels of serum estradiol and progesterone. Pathology examination of uterine and ovarian tissue showed that high dose group gained the best function recovery of ovarian and the highest value of endometrial repair score,but no significant difference between groups. Conclusion： Benglouting can reduce uterine blood loss of medical abortion and is contribute to ovarian and endometrial repair.