PET-CT最大标准摄取值定量评估胃癌组织中HER2的表达情况

Correlation between PET-CT maximum standardized uptake value and HER2 expression in gastric carcinoma

目的:探讨人表皮生长因子受体2(human epidermal growth factor receptor 2,HER2)表达程度与正电子发射断层扫描(positron emission tomography,PET)-CT标化摄取值(standardized uptake value,SUV)max的关系,从而定量评价胃癌组织中HER2表达情况,进而间接评价胃癌的生物学特性.方法:回顾性分析57例郑州大学第一附属医院胃腺癌患者的PET-CT扫描资料,测量最大标准摄取值.应用免疫组织化学方法检测胃癌中HER2的表达,用统计学方法分析SUVmax与HER2的相关性.结果:所有患者HER2阳性者28例,HER2表达阳性率为49.12%,按照统计学方法分析得出HER2阳性组SUVmax高于阴性组,且差异具有统计学意义(8.9357±4.21375 vs 4.6448±3.18597,P=0.000).SUVmax与HER2呈中度正相关,相关系数为0.581.以SUVmax为参考值绘制受试者工作特征曲线,曲线下面积为0.83,根据不同SUVmax值所对应特异度、灵敏度及约登指数可得出,当SUVmax值为5.800时所对应的约登指数越大,灵敏度为82.1%,特异度为79.8%.结论:胃癌组织中SUVmax与胃癌病灶中的H E R2的表达具有一定的相关性,能较好的评估胃癌的生物学特性.

AIM： To investigate the relationship between the maximum standardized uptake value（SUVmax） and human epidermal growth factor receptor 2（HER2） expression in gastric carcinoma. METHODS： Sixty-one patients who underwent PET-CT at our hospital and had pathologically proven gastric adenocarcinoma were included, and SUVmax was measured. HER2 expression was detected by immunohistochemistry. The correlation between SUVmax and HER2 expression was analyzed statistically.RESULTS： Of all the patients, 28 were positive for HER2, with a positive rate of 49.12%. The SUVmax for the HER2 positive group was 4.6448 ± 3.18597, which was significantly higher than that for the HER2 negative group（P = 0.000）. There was a moderate positive correlation between SUVmax and HER2, and the correlation coefficient was 0.581. According to the ROC analysis, the area under the curve of SUVmax was 0.83. Taking 5.800 as the threshold of SUVmax, the corresponding sensitivity and specificity were 82.1% and 79.8%, respectively. CONCLUSION ： There is a moderate correlation between SUVmax and HER2 in gastric adenocarcinoma, and SUVmax can help assess the biological characteristics of gastric cancer.