吸入型糖皮质激素治疗婴幼儿喘息性支气管炎疗效对比研究

The curative effect study of inhaled corticosteroids in the treatment of infant with wheezy bronchitis

目的：采用临床症状评分的方法，对吸入型糖皮质激素治疗婴幼儿喘息性支气管炎的临床疗效进行对比。方法选择临床诊断为喘息性支气管炎100例患儿，年龄4～23个月，根据临床症状评分，分为轻度（40例）、中度（30例）、重度（30例），不同程度患儿按随机数字表法均分为雾化组及对照组，比较治疗前后各组临床症状评分变化，判断其临床治疗效果。结果轻、中、重度喘息性支气管炎患儿中，雾化组治疗后24、48、72 h临床症状评分较对照组均明显降低，差异有统计学意义（P＜0.01或＜0.05）。轻、中、重度喘息性支气管炎患儿中，雾化组治疗后24 h临床症状评分逐渐下降，差异有统计学意义（P＜0.05）。轻、中度喘息性支气管炎患儿中，对照组治疗后48 h临床症状评分逐渐下降，差异有统计学意义（P＜0.05）；重度喘息性支气管炎患儿中，对照组治疗后72 h临床症状评分逐渐下降，差异有统计学意义（P＜0.05）。采用析因设计资料的方差分析结果显示，在治疗方法方面,雾化组与对照组比较差异有统计学意义（F=66.393、5.093、154.326， P＜0.01）。治疗时间方面，雾化组与对照组比较差异有统计学意义（F=263.836、182.568、75.587， P＜0.01）。在治疗方法＆#215;治疗时间方面，雾化组与对照组比较差异有统计学意义（F=13.956、6.414、5.628，P＜0.01）。结论吸入型糖皮质激素治疗轻、中、重度婴幼儿喘息性支气管炎能明显改善临床症状，降低临床症状评分。

Objective To study the curative effect of inhaled corticosteroids in the treatment of infant with wheezy bronchitis through clinical symptom score. Methods One hundred infant of 4-23 months old with wheezy bronchitis treated were enrolled. According to the clinical symptom score, they were divided into light group （40 cases）, moderate group （30 cases） and severe group （30 cases）. Patients in each group were divided into atomization group and control group by random digits table. The clinical symptom score was compared between before treatment and after treatment. Results In light, moderate and severe group, the clinical symptom scores 24, 48, 72 h after treatment in atomization group were significantly lower than those in control group （P〈0.01 or〈0.05）. In light, moderate and severe group,＆amp;nbsp;the clinical symptom scores in atomization group were significantly decreased 24 h after treatment （P 〈0.05）. In light and moderate group, the clinical symptom scores in control group were significantly decreased 48 h after treatment （P 〈 0.05）, and in severe group, the clinical symptom score in control group was significantly decreased 72 h after treatment （P 〈 0.05）. Factorial design data of variance analysis showed that in the treatment method, there were significantly differences between atomization group and control group （F=66.393, 5.093 and 154.326;P〈0.01）, in the treatment time aspect, there were significantly differences between atomization group and control group （F = 263.836, 182.568 and 75.587;P〈0.01）, and in terms of treatment method ＆#215; time, there were significantly differences between atomization group and control group （F = 13.956, 6.414 and 5.628; P 〈 0.01）. Conclusions Inhaled corticosteroids therapy in light, moderate and severe infant wheezy bronchitis can obviously improve the clinical symptoms and reduce the clinical symptom scores.