微小RNA-375在肿瘤中的表达及作用

Expression and role of microRNA-375 in cancer

微小RNA-375（miR-375）与多种肿瘤的发生发展密切相关,如肝癌、胃癌、胰腺癌、子宫内膜癌、食管癌、非小细胞肺癌等.miR-375相关的肿瘤发病机制主要包括其与特定靶基因结合,并在转录后水平降解mRNA或抑制蛋白翻译,发挥抑制细胞增殖、促进细胞凋亡、抑制侵袭转移等抑癌作用.miR-375有望成为肿瘤治疗的一个新靶点,并可能成为肿瘤诊断、治疗及预后判断的一个重要生物标志物.

MicroRNA-375 （miR-375） is closely related to the development of cancer,such as liver cancer,gastric cancer,pancreatic cancer,endometrial cancer,esophageal cancer,non-small cell lung cancer,etc.The mainly tumor pathogenesis related miR-375 includes that miR-375 is combined with specific target genes,can degrade mRNA or inhibit protein translation in the transcriptional level,and plays antitumor effect of inhibition of cell proliferation,promoting cell apoptosis and inhibiting the invasion and metastasis.miR-375 is expected to be a new target for cancer therapy,which may become an important biomarker for the diagnosis,treatment and prognosis of cancer.