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长非编码RNA GAS5在恶性肿瘤中的表达及作用 被引量：2

Expression and role of long non-coding RNA GAS5 in human carcinomas
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摘要 生长停滞特异性转录因子5（GAS5）是一种常见的长非编码RNA,近年来研究发现GAS5在多种恶性肿瘤如乳腺癌、宫颈癌、肺癌、消化系肿瘤、泌尿系肿瘤等中表达下调,与肿瘤的发展、转移和预后密切相关,成为肿瘤研究的新热点. Growth arrest special 5 （GAS5） is a common long non-coding RNA （lncRNA）.Recent studies find that lncRNA GAS5 is down-regulated in various tumors,such as breast cancer,cervical cancer,lung cancer,gastrointestinal cancers and urologic cancers.GAS5 is closely related to the development,metastasis and prognosis of cancers,which becomes a new hotspot in cancer research.
作者 胡以恒 张军
机构地区 南京医科大学附属南京医院(南京市第一医院)消化内科
出处 《国际肿瘤学杂志》 CAS 2016年第6期445-447,共3页 Journal of International Oncology
关键词 肿瘤 生长停滞特异性转录因子5 GROWTH ARREST SPECIAL 5 Neoplasms
分类号 R730.2 [医药卫生—肿瘤]
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参考文献19

  • 1Schneider C, King RM, Philipson L. Genes specifically expressed at growth arrest of mammalian ceils[ J]. Cell, 1988, 54(6) : 787-793.
  • 2Lucafo M, De Iudicibus S, Di Silvestre A, et al. Long noncoding RNA GAS5 : a novel marker involved in glucocorticoid response [ J ]. Curr Mol Med, 2015, 15(1) : 94-99.
  • 3Tu ZQ, Li R J, Mei JZ, et al. Down-regulation of long non-coding RNA GAS5 is associated with the prognosis of hepatocellular carcinoma[J]. Int J Clin Exp Pathol, 2014, 7(7) : 4303-4309.
  • 4Chang L, Li C, Lan T, et al. Decreased expression of long non-coding RNA GAS5 indicates a poor prognosis and promotes cell prolifera- tion and invasion in hepatocellular carcinoma by regulating vimentin [J]. Mol Med Rep, 13 (2) : 1541-1550.
  • 5Sun M, Jin FY, Xia R, et al. Decreased expression of long noncoding RNA GAS5 indicates a poor prognosis and promotes cell proliferation in gastric cancer[ J ]. BMC Cancer, 2014, 14 : 319.
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  • 7Lu X, Fang Y, Wang Z, et al. Downregulation of gas5 increases pan- creatic cancer cell proliferation by regulating CDK6 [ J ]. Cell Tissue Res, 2013, 354(3): 891-896.
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国际肿瘤学杂志
2016年 第6期

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