中国女性乳腺增生危险因素Meta分析

Meta-analysis on the risk factor of hyperplasia of manmary glands in Chinese female

目的 探讨我国女性乳腺增生的主要危险因素,为今后防治工作提供依据。方法 运用Meta分析方法对我国2000-2014年公开发表的有关乳腺增生危险因素的18篇文献进行定量综合分析。结果 母乳喂养、月经紊乱、流产次数、不规律饮食、痛经、初产年龄、怀孕次数的合并OR值（95%CI）分别为0.57（0.40-0.80）,1.62（1.23-2.14）,1.25（1.07-1.47）,2.48（1.16-5.31）,1.74（1.00-3.02）,1.28（1.16-1.42）,1.55（1.08-2.21）。结论 月经紊乱、流产次数、不规律饮食、痛经、初产年龄、怀孕次数是我国女性乳腺增生发病的主要危险因素,母乳喂养为保护性因素。

Objective To explore the main risk factors related to hyperplasia of mammary glands in China, and provide evidence for prevention. Methods 18 research papers published between 2000 and 2014 were analyzed, andthe re- sults of main risk factors of hyperplasia of mammary glands were quantitatively analyzed by Meta-analysis method. Results The pooled odds radio values and 95% CI of breast feeding, menstrual disorder, the numbers of abortion, irregular dietary, dysmenorrhea, the age of first delivery, the number of pregnancy were 0. 57 （0. 40 -0. 80）, 1.62 （ 1.23 -2. 14）, 1.25 （1.07-1.47）, 2.48 （1.16-5.31）, 1.74 （1.00-3.02）, 1.28 （1.16-1.42）, 1.55 （1.08-2.21）. Conclusion The main risk factors of hyperplasia of mammary glands among Chinese female were menstrual disorder, the numbers of abor- tion, irregular dietary, dysmenorrhea, the age of first delivery, the number of pregnancy, while breast feeding was a pro- tect factor.