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阿法替尼的合成路线图解 被引量：1

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摘要 分析阿法替尼(1)及其关键中间体4-[(3-氯-4-氟苯基)氨基]-6-硝基-7-[(S)-(四氢呋喃-3-基)-氧基]-喹唑啉(12)的合成方法,找到适合工业化生产的合成路线。通过中间体12合成阿法替尼的方法工艺简单,成本低,适合工业化生产。
作者 涂远彪 王敏 朱五福
机构地区 江西科技师范大学药学院
出处 《华西药学杂志》 CAS CSCD 2016年第3期317-320,共4页 West China Journal of Pharmaceutical Sciences
基金 国家自然科学基金资助项目(批准号:81460527) 江西省自然科学基金项目(20142BAB215020)
关键词 阿法替尼 酪氨酸激酶抑制剂 抗肿瘤 合成 工业化 合成路线图解
分类号 R914 [医药卫生—药物化学]
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参考文献23

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华西药学杂志
2016年 第3期

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