远志常用配伍的实验研究进展

Common Combinations of Polygalae Radix

对于中药材的"增效减毒"研究一直是中医药学工作者的一项长期、艰巨的历史任务,然而多数人主要将目光集中在雷公藤、附子、川乌、草乌等毒性较强的中药上,对于一些常用的、毒副作用少的中药缺乏足够的认识。远志是临床常用益智药,是目前抗衰益智类实验研究的热点之一。但远志有明显的胃肠副作用,且毒性成分即具有抗衰益智作用的远志皂苷。通过归纳近年来远志常用配伍的实验研究进展,包括远志-石菖蒲、远志-厚朴、远志-白蜜、远志-酸枣仁、远志-人参、远志-茯苓(茯神)、远志-甘草、远志-拳参等配伍,研究者发现几乎没有将益智、减毒相结合的实验研究,从有效性和安全性考虑,基于配伍学角度探讨远志"减毒增效"的机制,从实验室获得有价值的证据,对于指导远志的临床用药、开发新药具有重要意义。

It has been a long-term,arduous task for traditional Chinese medicine practitioners to study the ＂efficacy-enhancing and toxicity-reducing＂effect of Chinese herbal medicines. However,they mostly focused on the traditional Chinese herbs with a higher toxicity,such as Tripterygium wilfordii,Aconite Lateralis Radix Praeparata,Aconiti Radix and Aconiti Kusnezoffii,but paid less attention to commonly used herbs with less toxic and side effects. Polygala Radix is commonly used as a nootropic medicine in the clinic,and one of hot herbs in anti-aging and intelligence-reinforcing experiments at present. Polygala Radix has an obvious gastrointestinal side effect,and contains tenuigenin that has an anti-aging and intelligence-reinforcing effect but toxicity. By summarizing the recent advance in studies on common combinations of Polygala Radix,including Polygala RadixAcori Tatarinowii Rhizoma,Polygala Radix-Magnoliae Officinalis Cortex,Polygala Radix-Mel,Polygala RadixZiziphi Spinosae Semen,Polygala Radix-Ginseng Radix et Rhizoma,Polygala Radix-Poria（ Fushen）,Polygala Radix-Glycyrrhizae Radix et Rhizoma,Polygala Radix-Bistortae Rhizoma,researchers found almost no experimental study combing the intelligence-reinforcing and toxicity-reducing effects. Considering the effectiveness and safety,based on the compatibility,they studied Polygala Radix＇s ＂toxicity-reducing and efficacy-enhancing＂effects in the expectation of obtaining valuable evidence from laboratory,which is of great significance to guiding clinical medication of Polygala Radix and developing new drugs.