摘要
A series of amino alcohol derivatives containing coumarin and benzothiophene moieties was synthesized with 5-bromosalicylaldehyde and 5-bromo-2-thiophenecarboxaldehyde as starting materials, 6-substituted-3-chromanone and 4,5-dihydrobenzo[b]-thiophen-5（4H）-one as intermediates and Suzuki reaction and spiro-hydantoin hydrolysis as key steps. The structures of key intermediate and target compounds were confirmed by ^1H NMR, ^13C NMR IR and HRMS. Their characterization as sphirtgosine 1-phosphate（S 1P） receptor agonists was reported.
A series of amino alcohol derivatives containing coumarin and benzothiophene moieties was synthesized with 5-bromosalicylaldehyde and 5-bromo-2-thiophenecarboxaldehyde as starting materials, 6-substituted-3-chromanone and 4,5-dihydrobenzo[b]-thiophen-5（4H）-one as intermediates and Suzuki reaction and spiro-hydantoin hydrolysis as key steps. The structures of key intermediate and target compounds were confirmed by ^1H NMR, ^13C NMR IR and HRMS. Their characterization as sphirtgosine 1-phosphate（S 1P） receptor agonists was reported.
