消化道恶性肿瘤患者血清SOD水平与肿瘤分期的关系及化疗对其的影响

The association between serum SOD level and tumor stage for malignant digestive tract tumor and the impact of chemotherapy on serum SOD

目的检测消化道恶性肿瘤患者各分期血清超氧化物歧化酶(superoxide dismutase,SOD)水平并评价SOD在临床治疗过程中的意义。方法采用比色法(终点法)测定血清总SOD(total supemxide dismutase,T-SOD)含量,对101例初诊消化道恶性肿瘤患者进行检测;并观察67例晚期消化道恶性肿瘤患者化疗前、后血清SOD值动态变化。结果消化道恶性肿瘤患者血清SOD水平与健康人比较差异有统计学意义(P<0.05)。消化道恶性肿瘤患者血清SOD水平与肿瘤分期有关,Ⅰ期、Ⅱ期与健康组比较差异并无统计学意义(P>0.05),而Ⅲ期、Ⅳ期与健康组比较差异有统计学意义(P<0.05)。化疗1、2周期后患者血清SOD水平较化疗前差异无统计学意义(P>0.05),但化疗3、4周期后血清SOD水平上升,与化疗前比较差异有统计学意义(P<0.05)。结论消化道恶性肿瘤患者血清SOD水平低于正常值,且与肿瘤分期密切相关,化疗能使血清SOD值升高。

Objective To detect the level of serum superoxide dismutase（ SOD） in malignant digestive tract tumor patients at different clinical stages,and to evaluate the significance of SOD during clinical treatment. Methods The level of serum total SOD was examined by the colorimetric method in 101 newly diagnosed patients with malignant digestive tract tumor. The dynamic changes of serum SOD before and after chemotherapy in 67 patients with terminal malignant digestive tract tumor were further examined. Results The concentration of serum SOD differed between patients with malignant digestive tract tumor and normal people（ P〈0. 05）. The level of serum SOD is related with tumor staging. Stage Ⅰ and Stage Ⅱ tumor patients showed no significant different in SOD expression,compared with normal people（ P〉0. 05）,whereas the concentrations of SOD were obviously different in stage Ⅲ and stage IV patients（ P〈0. 05）. Moreover,the serum SOD level remained unchanged after one or two cycles of chemotherapy（ P〉0. 05）,but significantly increased after the third and fourth chemotherapy,compared with the SOD level before the chemotherapy（ P〈0. 05）. Conclusion The serum SOD level of patients with malignant digestive tract tumor is below the normal range,and tightly related to tumor stages. Chemotherapy can up- regulate serum SOD level.