期刊文献+

肝细胞癌基因靶向治疗新进展 被引量:4

下载PDF
导出
摘要 尽管肝细胞癌(hepatocellular carcinoma,HCC)的治疗已经取得很大进步,但是目前肝癌精确的致病原因知之甚少,使得其成为改善患者预后的一大限制因素。详尽地分析和描述基因在肿瘤形成中的分子机制,并针对每个患者的特质来预测预后,是现在个性化治疗追求的重要目标,将会彻底改善HCC的诊断和治疗水平,随着HCC基因靶点研究的进展,基因靶向治疗可以为合理的个体化药物治疗提供参考依据。
作者 邢荣春 郑军
出处 《实用肿瘤杂志》 CAS 2016年第3期285-288,共4页 Journal of Practical Oncology
  • 相关文献

参考文献36

  • 1Marquardt JU, Galle PR, Teufel A. Molecular diagnosis and therapy of hepatocellular carcinoma (HCC) : An e- merging field for advanced technologies [ J]. J Hepatol, 2012,56( 1 ) :267 - 275.
  • 2Bruix J, Sherman M. Management of hepatocellular car- cinoma: an update [ J ]. Hepatology, 2010, 53 ( 3 ) : 1020 - 1022.
  • 3Worns MA, Galle PR. Future perspectives in hepatocel- lular carcinoma [ J].Dig Liver Dis, 2010, 42 (3): S302 - 309.
  • 4Feinberg AP, Tycko B. The history of cancer epigenetics [J]. NatRev Cancer,2004,4(2):143-153.
  • 5Kumar V, Kato N, Urabe Y, et al. Genome-wide associ- ation study identifies a susceptibility locus for HCVin-duced hepatocellular carcinoma[J]. Nat Genet, 2011,43 (5) :455 -458.
  • 6Gao W, Kondo Y, Shen L, et al. Variable DNA methyl- ation patterns associated with progression of disease in hepatocellular carcinonms [ J ]. Carcinogenesis, 2008,29 (10) :1901 - 1910.
  • 7Lee S. Aberrant CpG island hypermethylation along mul- tistep hepatocarcinogenesis [ J]. Am J Pathol, 2003,163 (4) :1371 - 1378.
  • 8Um TH, Kim H, Oh BK, et al. Aberrant CpG island hy- permethylation in dysplastic nodules and early HCC of hepatitis B virusrelated human muhistep hepatocarcino- genesis [ J ]. J Hepato1,2011,54 ( 5 ) :939 - 947.
  • 9Hernandez-Vargas H, Larnbert MP, Le Calvez-Kelm F, et al. Hepatoeellular carcinoma displays distinct DNA methylation signatures with potential as clinical predictors [J]. PLoSOne,2010,5(3):e9749.
  • 10Lambert MP, Paliwal A, Vaissiere T, et al. Aben'ant DNA methylation distinguishes hepatocellular carcinoma associated with HBV and HCV infection and alcohol in- take [ J ]. J Hepatol, 2010,54 ( 4 ) :705 - 715.

二级参考文献7

  • 1Hsien-ChungYu,Jin-ShiungCheng,Kwok-HungLai,Chi-PinLin,Gin-HoLo,Chiun-KuLin,Ping-IHsu,Hoi-HungChan,Ching-ChuLo,Wei-LunTsai,Wen-ChiChen.Factors for early tumor recurrence of single small hepatocellular carcinoma after percutaneous radiofrequency ablation therapy[J].World Journal of Gastroenterology,2005,11(10):1439-1444. 被引量:17
  • 2郭连英,杨泷,施广霞,任含平,沈洁,钱振超.JNK/SAPKs信号转导通路在榄香烯抗肝癌效应中的作用[J].中国肿瘤生物治疗杂志,2005,12(3):202-205. 被引量:8
  • 3冉莉,文格波,曹仁贤.P53泛素化的非Mdm2依赖途径[J].国际病理科学与临床杂志,2007,27(5):414-416. 被引量:1
  • 4Hiroshi Imamura,Keiji Sano,Yasuhiko Sugawara,Norihiko Kokudo,Masatoshi Makuuchi.Assessment of hepatic reserve for indication of hepatic resection: decision tree incorporating indocyanine green test[J].Journal of Hepato - Biliary - Pancreatic Surgery.2005(1)
  • 5Marco Montorsi M.D.,Roberto Santambrogio M.D.,Paolo Bianchi M.D.,Matteo Donadon M.D.,Eliana Moroni M.D.,Antonino Spinelli M.D.,Mara Costa M.D.Survival and recurrences after hepatic resection or radiofrequency for hepatocellular carcinoma in cirrhotic patients: A multivariate analysis[J].Journal of Gastrointestinal Surgery.2005(1)
  • 6Ming Shi M.D.,Chang-Qing Zhang M.D.,Ya-Qi Zhang M.D.,Xiao-Man Liang M.D.,Jin-Qing Li M.D.Micrometastases of Solitary Hepatocellular Carcinoma and Appropriate Resection Margin[J].World Journal of Surgery.2004(4)
  • 7Nestor F. Esnaola M.D., M.P.H.,Gregory Y. Lauwers M.D.,Nadeem Q. Mirza M.D., M.P.H.,David M. Nagorney M.D.,Dorota Doherty Ph.D.,Iwao Ikai M.D.,Yoshio Yamaoka M.D.,Jean-Marc Regimbeau M.D.,Jacques Belghiti M.D.,Steven A. Curley M.D.,Lee M. Ellis M.D.,J. Nicolas Vauthey M.D.Predictors of microvascular invasion in patients with hepatocellular carcinoma who are candidates for orthotopic liver transplantation[J].Journal of Gastrointestinal Surgery.2002(2)

共引文献23

同被引文献42

引证文献4

二级引证文献14

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部