乌司他丁对老年肺癌患者根治术后认知功能障碍的影响

Effect of Ulinastatin on Cognitive Dysfunction in Elderly Patients with Lung Cancer after Radical Resection

目的分析总结乌司他丁对老年肺癌根治术后认知功能障碍的影响。方法以100例拟接受肺癌根治术的老年患者作为观察者,并采用随机数字表法将患者随机分为两组,每组50例。以在治疗过程中接受乌司他丁治疗者为观察组,以在治疗过程中接受生理盐水对照治疗者为对照组。对比两组各治疗时间点认知功能变化情况。结果两组术前、术后1 d、术后7 d及术后1个月4个时间点简易精神状态评价量表评分(MMSE评分)、术后恢复质量评估量表评分(PQRS评分)及韦氏成人记忆量表记忆商(MWS记忆商)均存在显著差异(P<0.05),两组术后各项评分均显著降低,而术后1 d、术后7 d及术后1个月间各项评分均呈升高趋势(P<0.05)。两组间术前各项评分比较未见统计学差异,而观察组术后1 d、术后7 d及术后1个月时各项评分均明显高于对照组(P<0.05)。结论乌司他丁可显著改善接受肺癌根治术治疗的老年患者的术后认知功能障碍。

Objective To analyze the effect of ulinastatin on cognitive dysfunction in elderly patients with lung cancer after radical resection. Methods 100 cases of elderly patients with lung cancer were randomly divided into 2 groups,50 cases in each group. In the course of treatment,patients received ulinastatin treatment in the observation group,the control group only received saline. The changes of cognitive function were compared between the 2 groups at different treatment time points. Results There were significant differences in mental state assessment rating scale（ MMSE score）,postoperative recovery quality assessment rating scale（ PQRS score） and wechsler adult memory scale memory quotient（ MWS memory quotient） among the preoperative,postoperative 1 d,postoperative 7 d and postoperative 1 month 4 time points in the 2 groups（ P〈0. 05）. The postoperative scores were significantly lower than preoperative（ P〈0. 05）. There were increased trend of the scores in postoperative 1 d,postoperative 7 d and postoperative 1 month（ P〈0. 05）. There was no statistical difference between the 2 group in scores（ P〈0. 05）.The scores in the observation group postoperative 1 d,postoperative 7 d and postoperative 1 month were significantly higher than those of the control group（ P〈0. 05）. Conclusion Ulinastatin can significantly improve postoperative cognitive function in elderly patients with lung cancer after radical resection.