多西他赛联合奥沙利铂和替吉奥一线治疗晚期胃癌的疗效观察

Observation of Clinical Effect of Docetaxel Combined with Oxaliplatin and S-1 Capsule for Advanced Gastric Cancer as First-line Chemotherapy

目的探讨多西他赛联合奥沙利铂和替吉奥胶囊一线治疗晚期胃癌的临床疗效和毒副作用。方法 96例晚期胃癌患者,随机分成观察组和对照组,每组48例。观察组采用多西他赛联合奥沙利铂和替吉奥胶囊的治疗方案,对照组采用奥沙利铂联合替吉奥的治疗方法。比较评价2组的治疗效果和不良反应。结果观察组患者的总治愈率明显高于对照组(P=0.0069<0.01),免疫功能得到更好的增强(P<0.05);观察组粒细胞减少、神经毒性、脱发和手足综合征的发生率低于对照组(P均<0.05),其他不良反应的发生率组间无明显差异(P>0.05)。结论多西他赛联合奥沙利铂和替吉奥胶囊一线治疗晚期胃癌有很好的疗效,不良反应较少且可耐受,值得临床广泛应用。

Objective To discuss the efficacy and adverse reactions of docetaxel combined with oxaliplatin and S-1 capsule as first-line chemotherapy for advanced gastric cancer. Methods 96 patients with advanced gastric cancer were randomly divided into the observation group and the control group,each with 48 cases. The observation group were treated with docetaxel,oxaliplatin and S-1 capsule,while the control group were treated with oxaliplatin and S-1 capsule. Efficacy and toxicities of the 2groups were evaluated and compared. Results The total cure rate of the observation group was higher than that of the control group（ P = 0. 0069 0. 01）. Immune function of the observation group increased significantly（ P〈0. 05）. The frequency of leucopenia,neurosensory abnormity,alopecia and hand-foot syndrome of the observation group were lower than that of the control group respectively（ P〈0. 05）. There was no significant difference in other adverse reactions（ P〉0. 05）. Conclusion Docetaxel combined with oxaliplatin and S-1 capsule in the first-line treatment of advanced gastric cancer is effective with less toxicities which can be tolerable for patients. It is worthy of widely application in clinical practice.