蛋白Artemin在三阴性和非三阴性乳腺癌组织中的表达及其意义

Expression and Clinical Significance of Artemin Protein in Triple-negative and Nontriple-negative Breast Cancer Tissues

目的研究蛋白Artemin在三阴性(triple-negative breast cancer,TNBC)和非三阴性(non-triplenegative breast cancer,non-TNBC)乳腺癌组织中的表达情况,进一步探索蛋白Artemin与乳腺癌临床病理及预后的关系,为临床判断其生物学行为及评估预后提供有力证据。方法回顾性分析2005年7月至2009年7月间河北医科大学附属沧州市中心医院收治的乳腺癌患者,根据入选标准,随机抽取三阴性及非三阴性乳腺癌各120例作为研究对象。运用统计学方法对所有数据进行t检验、χ2检验,生存分析采用寿命表法、Kaplan-Meier曲线,Cox比例风险模型进行检验。结果蛋白Artemin阳性率为61.7%(148/240),在TNBC中的阳性率为82.5%(99/120),明显高于non-TNBC中的阳性率41.0%(49/120);在TNBC组中蛋白Artemin阳性与阴性的患者1、3、5年生存率分别为93.0%、78.0%、50.0%vs.100.0%、89.0%、79.0%;non-TNBC组中蛋白Artemin阳性与阴性的患者1、3、5年生存率分别为98.0%、89.0%、89.0%vs.99.0%、97.0%、97.0%,差异具有统计学意义(P<0.05)。结论蛋白Artemin在TNBC乳腺癌中的表达明显高于non-TNBC,生存率明显降低,是判断乳腺癌恶性程度的重要指标,值得推广研究。

Objective To investigate the expression of Artemin protein in triple-negative breast cancer（TNBC） and non-triple-negative breast cancer（non-TNBC） tissues, and to further explore its relationship with clinical pathology and the prognosis of tumor, to provide powerful evidence for judging biological behaviour and evaluating the prognosis. Methods According to the criteria, 240 cases of breast cancer（120 cases of TNBC, 120 cases of non-TNBC, respectively） were selected randomly and admitted to Cangzhou Central Hospital of Hebei Medical University from July 2005 to July 2009. The expression of Artemin was detected in tumor tissues. All data were analyzed using t test and chi-square test, and the survival of patients was analyzed using the life table and Kaplan-Meier curves. The COX proportional hazards model was also used for the prognosis. Results The positive expression rate of Artemin protein was 61.7%（148/240）. The positive rate of Artemin in TNBC tissues was higher than that in non-TNBC tissues [82.5%（99/120） vs. 41.0%（49/120）]. The survival rates of 1-, 3-, 5-year in the groups of TNBC with positive Artemin, TNBC without Artemin, non-TNBC with positive Artemin, and non-TNBC without Artemin were 93.0%, 78.0%, 50.0% vs. 100.0%, 89.0%, 79.0% vs. 98.0%, 89.0%, 89.0% vs. 99.0%, 97.0%, 97.0%, respectively（P〈0.05）. Conclusion Artemin is clearly expressed higher in TNBC than non-TNBC tissues, and is one of the important indicators for the prognosis of breast cancer, with great value for research.