摘要
目的：探讨首次静脉注射丙种球蛋白（IVIG）无反应性川崎病（KD）的相关因素及再治疗效果。方法：对本院2006年1月~2015年8月住院诊治的46例KD患儿的临床资料进行回顾性分析。结果：46例KD患儿急性期应用IVIG治疗无反应6例,占总数的13.04%;所有无反应组患儿均出现不同程度的冠脉扩张,与敏感组（40%）相比,无反应组冠脉病变（CAL）发生率显著增高（P〈0.01）。再治疗选择中,无反应组6例全部接受IVIG再次治疗,有效5例;1例对IVIG仍无反应,予糖皮质激素治疗后好转。结论：本组病例中IVIG无反应KD发生率约13.04%,CAL发生率高。对初次IVIG无效患儿可再次使用静脉注射丙种球蛋白治疗,若仍无效可予糖皮质激素治疗。
Objective：To summarize the clinical characteristics of children with intravenous immunoglobin（IVIG） resistant Kawasaki disease（KD）.Methods：Forty six patients with KD from Jan.2006 to Oct.2015 treated in our hospital were analyzed.Results：There were 6（13.04%）patients failed to response to initial IVIG treatment.All 6 patients resistant to IVIG had coronary artery lesions（100%）,compared with 16 patients who were IVIG responsive（P〈0.01）.Among patients resistant to IVIG who were treated with a second IVIG 5 patients became responsive,only one need glucocorticoid hormone therapy.Conclusion：The proportion of IVIG resistant KD in our hospital was 13.04%.Coronary artery lesions was more common in these patients.Additional infusion of IVIG should be considered.
出处
《中日友好医院学报》
2016年第3期143-146,共4页
Journal of China-Japan Friendship Hospital
关键词
川崎病
丙种球蛋白
危险因素
治疗
Kawaski disease
immunoglobulin
risk factor
treatment
