摘要
From the dried roots and leaves of Tripterygium wilfordii^(1.2),a new diter- penoid triepoxide,16-hydroxytriptolide was isolated,and its structure and stereochemistry elucidated as 16-(S)-hydroxy-triptolide on the basis of spectral data(IR, MS, UV,~1HNMR,^(13)CNMR,2d-NMR,Selective Long-range DEPT)and x-ray crystallographic analysis.This compound showed definite antiinflammatory action,strong immunosuppressive and antifertile activities.In addition,a known compound,triptolide was also isolated and all the spectral signals of^1 HNMR and ^(13)CNMR were assigned.
从雷公藤(Tripterygiurn wilfordii Hook f.)的叶、根及制剂“雷公藤多甙”中分离出一个新的三环氧二萜内酯化合物-16-羟基雷公藤内酯醇(L_2)。该化合物是一种白色簇状结晶,熔点232-233.5℃,分子式为C_20H_24O_7。根据光谱(UV,IR,MS,~1HNMR,~13CNMR,2d-NMR和Se-lective Long-range DEPT)数据分析,确定了其化学结构,并通过X-射线晶体分析确证了它的立体化学。15-C为“S”构型的手性碳。药理试验表明,16-羟基雷公藤内酯醇具有较强的抗炎、免疫抑制和雄性抗生育活性。另外,还分离到已知化合物雷公藤内酯醇,并通过2d-NMR等光谱分析归属了全部碳和质子的NMR光谱峰。
