天然植物复方提取液对摄食高脂饲料小鼠的降脂减肥作用

Effect of Extracts Solution from Natural Plants on the Lipid-lowering, Anti-obesity of the Mice Fed a High-fat Diet

目的：研究含荷叶、山楂、决明子、黄精的复方提取液对摄食高脂饲料小鼠的降脂减肥作用。方法：将63只健康雄性ICR小鼠随机分成9组：正常组喂食基础饲料,模型I组喂饲高脂饲料,拮抗组（I～Ⅲ）喂饲高脂饲料灌胃低、中、高剂量的提取液。剩余4组连续喂饲高脂饲料3周建立肥胖模型后,模型Ⅱ组喂食基础饲料,相应治疗组（I～Ⅲ）喂食基础饲料并按拮抗组方式灌胃给药。试验结束后,测试小鼠血清中的相关生化指标及小鼠脂肪系数和李氏指数。结果：与模型组相比,给药组明显提高了小鼠血清中SOD活性（P〈0.01）,显著降低了血清中MDA,LDLC,TG,TC的含量及李氏指数和脂肪系数（P〈0.05）。结论：该天然植物配方液可有效降低摄食高脂饲料引起的小鼠血脂指标,对其导致的营养型肥胖有缓解和治疗作用,且拮抗组优于治疗组。

Objective： To investigate the effect of extracts solution compounded from Lotus leaf, Hawthorn, Semen Cassiae and Crataegus pinnatifida Bge on lipid-lowering and anti-obesity of the mice fed a high-fat diet. Methods ： 63 male ICR mice were randomly divided into 9 groups. Blank group was fed a basic diet; model groups were fed high-fat diet; antagonistic groups（I-Ⅲ） were fed high-fat diet and treated with extracts solution at low, medium and high dose.The remaining four groups were fed high-fat diet for three consecutive weeks establishing obesity model, then model group II was fed basic diet; corresponding treatment group（I-Ⅲ） were fed basic diet and administrated by the antagonistic groups manner. After the test, related biochemical indexes in mice serum were detected; Lee＇s index and fat factor were measured. Results： Compared to model groups, activity of SOD in drug groups significantly improved（P〈0.01）,serum MDA, LDLC, TG, TC and Lee＇s index as well as fat factor reduced significantly（P〈0.05）. Conclusions： This natural plant complex extracts solution can lower the serum lipid of the mice fed by high-fat diet, alleviate and therapy the nutritional obesity effectively. Besides the effectiveness of lipid-lowering and anti-obesity to the antagonistic groups were better than the treatment groups.