苦参素注射液治疗慢性丙型病毒性肝炎肝纤维化的疗效观察

Observation on Efficacy of Marine Injection in Treatment of Liver Fibrosis of Chronic Hepatitis C

目的:探讨苦参素注射液治疗慢性丙型病毒性肝炎(chronic hepatitis C,CHC)肝纤维化的临床效果。方法:选择新疆和田地区人民医院收治的116例CHC肝纤维化患者作为研究对象,按随机数字表法分为观察组和对照组,每组各58例。对照组患者给予常规治疗,观察组在对照组治疗的基础上加用苦参素注射液,观察2组患者的血清肝纤维化指标、丙型肝炎病毒核糖核酸(HCV-RNA)、肝功能及不良反应发生情况。结果:治疗12周后,观察组患者透明质酸、层黏连蛋白、Ⅲ型前胶原、Ⅳ型胶原均较治疗前有明显改善,且观察组各指标改善情况明显优于对照组,差异有统计学意义(P<0.05);观察组患者HCV-RNA转阴率为32.76%(19/58),明显高于对照组的20.69%(12/58),差异有统计学意义(P<0.05);2组患者的丙氨酸转氨酶、天门冬氨酸转氨酶、总胆红素均较治疗前有明显改善,且观察组各指标改善情况明显优于对照组,差异有统计学意义(P<0.05);2组患者在治疗过程中均未见严重不良反应。结论:苦参素注射液治疗CHC肝纤维化疗效较好,安全性较高,值得临床推广。

OBJECTIVE： To investigate the clinical effects of marine injection in treatment of liver fibrosis of chronic hepatitis C. METHODS： 116 cases with liver fibrosis of chronic hepatitis C admitted into Xinjiang Hotan Region People＇s Hospital were selected to be divided into observation group and control group via the random number table,with 58 cases in each. The control group were treated with conventional treatment,while the observation group additionally received marine injection. The serum liver fibrosis indicators,HCV-RNA,liver function and incidence of adverse reactions were observed in two group of patients. RESULRTS： After treatment of 12 weeks,hyaluronic acid（ HA）,laminin（ LN）,procollagen Ⅲ（ PC-Ⅲ）,collagen Ⅳ had been significantly improved compared with before treatment,and the improvement of observation group were better than that of control group,with statistical significance（P〈0. 05）. The negative conversion ratio of HCV-RNA in observation group were 32. 76%（ 19 /58）,was higher than that of control group [20. 69%（ 12 /58） ], with statistically significant difference（P〈0. 05）. The alanine aminotransferase（ ALT）,aspartate aminotransferase（ AST）,total bilirubin（ TBIL） of two group of patients had been significantly improved compared with before treatment,and the improvement of observation group were better than that of control group,with statistical significance（P〈0. 05）. There were no severe adverse reactions in two group of patients during the treatment process. CONCLUSIONS： Marine injection in treatment of liver fibrosis of chronic hepatitis C is effective,with high safety,which is worthy of clinical application and promotion.