3种剂型黄体酮治疗功能性子宫出血的疗效观察及药物经济学研究

Observation on Efficacy of Three Forms of Progesterone in Treatment of Dysfunctional Uterine Bleeding and Pharmacoeconomic Evaluation

目的:探讨3种剂型黄体酮治疗功能性子宫出血的疗效及药物经济学。方法:选取牡丹江医学院红旗医院2014年1月—2015年1月收治的150例功能性子宫出血患者,按随机数字表法分为3组各50例。对照组患者给予黄体酮胶囊治疗,观察组1组患者给予黄体酮阴道凝胶治疗,观察2组患者给予黄体酮栓治疗,3个月为1疗程。比较3组患者的临床疗效、子宫内膜厚度、雌二醇、促卵泡生成素、不良反应发生率及药物成本-效果比。结果:观察1组患者总有效率为88%(44/50),观察2组为96%(48/50),对照组为76%(38/50),3组的差异均有统计学意义(P<0.05);治疗后,观察2组患者的子宫内膜厚度、雌二醇、促卵泡生成素分别为(5.1±1.8)mm、(43.28±0.3)pg/ml、(9.81±1.0)U/L,观察1组分别为(6.2±1.5)mm、(51.02±2.1)pg/ml、(10.04±1.2)U/L,对照组分别为(9.8±2.4)mm、(68.72±5.0)pg/ml、(2.48±1.6)U/L,3组的差异均有统计学意义(P<0.05);3组患者不良反应发生率、成本-效果比的差异均有统计学意义(P<0.05)。结论:黄体酮栓治疗功能性子宫出血的可提高临床疗效,降低不良反应发生率,药物经济学价值显著。

OBJECTIVE： To investigate the efficacy of three forms of progesterone in treatment of dysfunctional uterine bleeding and pharmacoeconomic evaluation. METHODS： 150 patients with dysfunctional uterine bleeding admitted into Hongqi Hospital of Mudanjiang Medical University from Jan. 2014 to Jan. 2015 were selected to be divided into three groups via the random number table,with 50 cases in each. The control group were treated with Progesterone capsules,the observation group one received progesterone vaginal gel,and the observation group two were given progesterone suppository; three months for a treatment course. After treatment,the clinical efficacy,endometrial thickness,estradiol,follicle stimulating hormone,incidence of adverse drug reactions and drug cost effect ratio were compared among three group of patients. RESULTS： The total effective rate of observation group one was 88%,and observation group two was 96%,and control group was 76%,the differences among three groups were statistically significant（P〈0. 05）. In observation group two,the endometrial thickness was（ 5. 1 ± 1. 8） mm,estradiol was（ 43. 28 ±0. 3） pg/ml,follicle stimulating hormone was（ 9. 81 ±1. 0） U/L,observation group one were（ 6. 2 ± 1. 5） mm、（ 51. 02 ± 2. 1） pg /ml、（ 10. 04 ± 1. 2） U/L,the control group were（ 9. 8 ± 2. 4） mm,（ 68. 72 ± 5. 0） pg /ml and（ 2. 48 ± 1. 6） U/L,the differences among three groups were statistically significant（P〈0. 05）. The differences on the incidence of adverse drug reactions and the drug cost effect ratio among three groups were statistically significant（P〈0. 05）. CONCLUSIONS： Progesterone in treatment of dysfunctional uterine bleeding can improve the clinical efficacy in patients,reduce the incidence of adverse drug reactions,with significant pharmacoeconomic value.