冠心病患者地高辛中毒的药学监护

Pharmaceutical Care for Coronary Heart Disease Patients with Digoxin Poisoning

目的:开展治疗药物监测,提高对地高辛中毒患者的药学监护,促进合理用药。方法:在血药浓度监测过程中发现1例地高辛中毒的老年患者,临床药师通过分析病情,结合患者自身的特点和地高辛血药浓度,分析和讨论该患者地高辛中毒的影响因素,包括年龄、性别、肝肾功能、给药剂量和联合用药等方面,并对患者进行有益的监护。结果与结论:通过血药浓度监测及时发现地高辛中毒患者,并采取停药、利尿等有效措施,避免病情恶化。临床药师应对地高辛血药浓度监测结果进行及时、准确的分析,协助医师调整给药方案,以避免或减少地高辛中毒发生。

OBJECTIVE： To development the monitoring of therapeutic drugs,and improve pharmaceutical care for coronary heart disease patients with digoxin poisoning,so as to promote rational drug use. METHODS： During the process of monitoring of blood concentration,one cases of elderly patient with digoxin poisoning was found. Through analyzing the disease conditions combined with the patients＇ characteristics and blood concentration of digoxin,the clinical pharmacists analyzed and discussed the influencing factors of digoxin poisoning to find out the causes,including age,gender,liver and kidney function,dose and drug combination,and provided beneficial pharmaceutical care for patients. RESULTS CONCLUSIONS： Through the monitoring of blood concentration,patient with digoxin poisoning was found immediately, and effective measures as drug withdrawal, diuresis were took to avoid the deterioration of diseases. The clinical pharmacists should analyze the blood concentration of digoxin promptly and exactly,and assist clinicians to regulate the rational dosage regimen,in order to reduce or avoid digoxin poising.