卤米松乳膏联合青鹏软膏治疗局限性湿疹的近远期疗效分析

Recent and forward efficacy analysis on Halogen Betamethasone Cream combined with Qingpeng Ointment in treatment of localized eczema

目的探讨卤米松乳膏联合青鹏软膏治疗局限性湿疹临床效果。方法选取2012年1月—2013年1月150例局限性湿疹患者为研究对象,随机分成2组,对照组75例,予卤米松乳膏治疗,观察组75例,在对照组基础上加用青鹏软膏治疗,观察治疗后相关指标变化情况。结果总疗效上,对照组痊愈率24%、总有效率81.34%,观察组痊愈率34.67%、总有效率90.67%,两组比较差异有统计学意义(P<0.05);症状积分上,两组治疗后瘙痒积分、皮损积分、丘疹积分、红斑积分较治疗前均明显下降,治疗前后比较差异均有统计学意义(P<0.05),观察组治疗后在以上症状积分上较对照组治疗后改善更加明显,两组比较差异有统计学意义(P<0.05);不良反应上,对照组不良反应总发生率为20%,观察组不良反应发生率为5.33%,两组比较差异有统计学意义(P<0.05);远期效果上,对照组复发率28%,皮损缩小面积为51%,症状积分为(3.12±0.53)分;观察组复发率6.67%,皮损缩小面积为71%,症状积分为(1.11±0.34)分,两组比较差异有统计学意义(P<0.05)。结论卤米松乳膏联合青鹏软膏治疗局限性湿疹近远期疗效满意。

Objective To investigate the clinical efficacy of Halogen Betamethasone Cream （HBC） combined with Qingpeng Ointment （QO） in treatment of localized eczema, in order to choose the best drug and improve the clinical treatment level. Methods Patients （150 cases） with localized eczema from January 2012 to January 2013 were chosen, and divided into two groups, each group had 75 cases. The control group were given HBC, the observation were taken with QO on the base of control group, the relevant index changes were observed. Results The total healing rate of control group was 24%, the total efficacy was 81.34%, while those in the observation group were 34.67% and 90.67%., which had significant differences （P 〈 0.05）. The itching, skin lesions, integral, pimples, erythema, integral symptom score of two groups after treatment were lower than before, with significant difference （P 〈 0.05）. The score of observation group decreased more obviously than that of control group （P 〈 0.05）. The adverse reactions rate of control group was 20%, while that in the observation group was 5.33%, with significant difference （P 〈 0.05）. In long-term efficacy, the recurrence rate of control group was 28%, the skin contraction area was 51%, the symptom score was （3.12 ± 0.53）, while those in the observation group were 6.67%, 71%, and （1.11 ± 0.34）, with significant differences （P 〈 0.05）. Conclusion The recent and forward efficacy of HBC combined with QO in treatment of localized eczema is satisfactory.