白藜芦醇降血尿酸、抗炎作用研究进展

Research progress on lowering uric acid and anti-inflammation effect of resveratrol

白藜芦醇是一种多酚类化合物,主要存在于葡萄、虎杖和花生等多种植物中,具有许多重要的生理活性,目前主要用于膳食补充剂、食品饮料和化妆品领域。药理研究发现白藜芦醇具有显著的降血尿酸和抗炎活性,有望开发为降尿酸和抗类风湿性关节炎的新药。就白藜芦醇体内外降血尿酸的药理作用、对痛风性炎症和类风湿性关节炎炎症的调节作用、以及对类风湿性关节炎滑膜细胞增殖抑制作用进行综述,为将其开发为降尿酸和抗痛风及治疗类风湿性关节炎的新药提供参考。

Resveratrol is a kind of polyphenol compound, mainly exists in Vitis vinifera, Polygonum cuspidatum, Arachis hypogaea and other plants, with many important physiological activities, mainly used in dietary supplements, beverage, and cosmetic fields. Pharmacological study found that resveratrol had significant uric acid-lowering and anti-inflammatory activities, and it was possible for resveratrol to develop as a kind of new drug to treat hyperuricemia and rheumatoid arthritis. The mechanism of resveratrol lowering uric acid, treating the inflammation of gout and rheumatoid arthritis and inhibiting the excessive proliferation of synovial cells were summarized in this paper. It would give reference for future exploitation of resveratrol to treat gout and rheumatoid arthritis.