雌激素受体、孕激素受体及原癌基因Her-2在肺腺癌中的表达

Expression of ER,PR and C-erb B-2 with lung adenocarcinoma

目的探讨雌激素受体（ER）、孕激素受体（PR）及原癌基因Her-2（C-erb B-2）在肺腺癌发生发展过程中的作用。方法选择2013年3月~2015年2月在我院手术治疗的肺腺癌患者组织切块60例为研究对象。分析不同性别、年龄、分化程度、临床分期患者肺腺癌中ER、PR及C-erb B-2的表达,分析肺腺癌患者组织中C-erb B-2的表达与ER、PR表达的相关性,分析骨转移患者与无骨转移患者肺腺癌组织中ER、PR、C-erb B-2的表达。结果 60例患者,14例ER阳性表达,占23.3%,13例PR阳性,占21.7%,6例C-erb B-2阳性,占10.0%。分化程度越低的患者ER阳性率及C-erb B-2阳性率越高（P〈0.05）。不同性别、临床分期肺腺癌患者组织中ER、PR及Cerb B-2表达无差异（P〉0.05）。相关性分析：C-erb B-2与ER表达呈显著正相关的关系（r=0.461）,C-erb B-2表达与PR呈正相关（r=0.326）;C-erb B-2与ER及PR均为阳性呈显著正相关的关系（r=0.329）,ER与PR表达无相关性（r=0.081）。骨转移患者与无骨转移患者肺腺癌组织中ER、PR及C-erb B-2表达无差异（P〉0.05）。结论肺腺癌中均可表达一定程度的雌激素受体、孕激素受体及原癌基因Her-2水平。

Objective To discuss expression of ER,PR and C-erb B-2 with lung adenocarcinoma.Methods Diced tissues of 60 cases with lung adenocarcinoma from Mar 2013 to Feb 2015 were selected.ER,PR and C-erb B-2 levels in patients of different sex,age,degree of differentiation,clinical stage were analyzed.Association of C-erb B-2 expression with ER and PR was analyzed.ER,PR and C-erb B-2 levels in patients with bone metastases and non bone metastasis were analyzed.Results In 60 cases,ER positive expression in 14 cases,accounted for 23.3%,13 cases of PR positive,accounted for 21.7%,and 6 cases of C-erb B-2 positive,accounted for 10%.ER and C-erb B-2 positive rates in patients with the lower the degree of differentiation were higher（P〈0.05）.ER,PR and C-erb B-2 positive rates in patients with different sex,there was no significant difference in the clinical stage（P〉0.05）.C-erb B-2 and ER expression was significantly positive correlation relationship（r=0.461）,C-erb B-2 expression and PR were positively correlated（r=0.326）;C-erb B-2,ER and PR were positive significant positive correlation relationship（r=0.329）,ER and PR expression no correlation（r=0.081）.ER,PR and C-erb B-2 expressions showed no significant difference in patients with bone metastases and non bone metastasis（P〉0.05）.Conclusion ER,PR and C-erb B-2 express in lung adenocarcinoma.