川崎病患儿急性期免疫功能变化及其意义

Change of immunity condition with Kawasaki disease in the acute period

目的探讨川崎病(KD)患儿急性期细胞免疫和体液免疫功能的变化,以及其对临床诊治的意义。方法选取2014年1月~2015年6月本院收治的KD患儿50例作为KD组,以及同期健康体检儿童50例为对照组,分别测定外周血淋巴细胞亚群(CD3^+、CD4^+、CD8^+、CD4^+/CD8^+、CD16^+56)与血清免疫球蛋白(IgG、lgA、IgM)水平,比较两组之间的变化。结果与对照组比较,KD组的CD3^+、CD4^+、CD8^+、CD4^+/CD8^+、IgG、IgA、IgM水平均明显升高(P<0.05),而CD16^+56则出现下降(P<0.05)。结论 KD患儿在急性期存在免疫系统的高度活化。

Objective To analyze the immunity condition in acute period children with Kawasaki disease.Methods Selected 50 children with KD and 50 healthy children,which were treated in our hospital from January 2014 to June2015,were divided into KD group and control group.The level variation of lymphocyte subsets（CD3＋,CD4＋,CD8＋,CD4＋/CD8＋,CD16 ＋56）and immune globulin（Ig G,Ig A,Ig M） were compared between two groups.Results Compared with the control group,the level of CD3＋,CD4＋,CD8＋,CD4＋/CD8＋,Ig G,Ig A,Ig M increased（P〈0.05） in the children with KD,while the level of CD16＋56 decreased（P〈0.05） at the same time.Conclusion Children in the acute period of KD have active function in immunity condition,which means their immune system activated.