大脑中动脉狭窄患者的认知功能变化

Changes of cognitive function in patie nts with middle cerebral artery stenosis

目的 探讨大脑中动脉狭窄患者认知功能的变化。方法 选取福建省老年医院神经内科门诊和病房2014年10月~2016年1月的125例患者为研究对象,分为正常、轻度、中度和重度四组,比较四组患者MMSE、MOCA,并通过言语性记忆测试、视觉记忆测试、执行能力测试及信息处理速度测试比较四组患者认知功能是否存在明显差异。结果 与正常、轻度大脑中动脉狭窄组患者相比,中度狭窄、重度狭窄患者MMSE及MOCA差异具有统计学意义（P〈0.05）;四组患者的言语性记忆、视觉记忆、执行能力及信息处理速度等差异具有统计学意义（P〈0.05）。结论 不同严重性的大脑中动脉狭窄对患者认知功能损害不同,需要根据患者情况制定有针对性治疗方案,以改善患者的认知功能。

Objective To discuss the changes of cognitive function in patients with middle cerebral artery stenosis （MCAS）. Methods All 125 patients treated in our department from October 2014 to January 2016 were selected as subjects and divided into normal group, mild group, moderate group and severe group. Differences of MMSE and MOCA were compared, and differences of cognitive function were also compared through verbal memory test, visual memory test,physical performance test and information processing rate test. Results There were significantly differences in MMSE and MOCA in patients with moderate and severe MCAS when compared with those of normal patients and mild MCAS patients（P〈0.05）. There were significantly differences in verbal memory,visual memory,physical performance and information processing rate among four groups （P〈0.05）. Conclusion MCAS of various severities has different degrees of cognitive impairment to patients. Specific therapies should be formulated based on the condition of patients to improve the cognitive function of patients.