呼吸内科病房感染铜绿假单胞菌的耐药探讨

Drug resistance of pseudomonas aeruginosa infected in respiratory medical ward

目的整理我院呼吸科内科病房患者的临床资料，探讨呼吸内科病房患者铜绿假单胞菌的感染情况以及耐药性。方法选取我院2014年1月～2015年12月收治的1028例呼吸内科病房患者，对其进行标本采集，并通过全自动微生物分析仪进行铜绿假单胞菌检验，并进行药敏实验。结果通过痰液、尿液等标本共分离出铜绿假单胞菌占4022株，占菌株总数的40．0％，2014年阿米卡星的耐药株数为1000株，2015年为905株；2014年亚胺培南的耐药菌株为1207株，2015年为704株；2014年头孢类药物的耐药菌株为1408株，2015年为900株；2014年环丙沙星的耐药菌株为1600株，2015年为400株。2014～2015年我院铜绿假单胞菌的感染率逐年升高。结论呼吸内科患者当中，我院2014～2015年铜绿假单胞菌的感染率极高。且逐年上升，铜绿假单胞菌对于药物的耐药性为多重耐药性，为保证患者的临床治疗效果，应谨慎使用抗菌药物。

Objective To review the clinical materials of patients in respiratory medical ward of our hospital and to discuss the infection status and drug resistance of pseudomonas aeruginosa infected in respiratory medical ward. Methods 1028 patients in the respiratory medical ward of our hospital treated from January 2014 to December 2015 were selected and their samples were collected to be examined by full-automatic microbiology analyzer for pseudomonas aeruginosa, and susceptibility testing was conducted. Results A total of 4022 strains of pseudomonas aeruginosa were isolated from samples of sputum and urine, accounting for 39.9% of all bacterial strains. There were 1000 strains of amikacin-resistance in 2014, and 905 in 2015; 1207 strains of imipenem-resistance in 2014, and 704 in 2015; 1048 strains of cephalosporin-resistance in 2014, and 900 in 2015; and 1600 strains of ciprofloxacin-resistance in 2014, and 400 in 2015. From 2014 to 2015, the infection rate of pseudomonas aeruginosa was rising by years. Conclusion The infection rate is very high and rising among patients in our department from 2014 to 2015, and pseudomonas aeruginosa shows multi-drug resistance. To guarantee the clinical therapeutic effect of patients, antibacterial agents should be used with caution.