4-(N-乙基-3-甲基苯胺基)丁酸甲酯的合成

Synthesis of 4-( N-ethyl-3-methylanilino) butanoic Acid Methyl Ester

以γ-丁内酯为起始原料,经开环氯化和醇解反应合成4-氯丁酸甲酯(2);2与N-乙基间甲苯胺经亲核取代反应合成了4-(N-乙基-3-甲基苯胺基)丁酸甲酯,纯度97.5%,总收率75.3%,其结构经1H NMR确证。

4-Chlorobutyric acid methyl ester （2） was prepared by ring-opening chlorination, alcohol reaction, using 1,4-butyrolactone as the starting material. 4-（N-ethyl-3-methylanilino）butanoic acid methyl ester in total yield of 75.3 % with purity of 97.5 % was synthesized by nucleophilic substitution of 2 with N-ethyl-m-toluidine. The structure was confirmed by l H NMR.