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血栓弹力图评估重组人白细胞介素-11对血小板减少症患者的改善血小板功能作用 被引量:1

Using thrombelastography evaluate the clinical efficacy of recombinant human interleukin-11 for treatment of thrombocytopenia
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摘要 目的:研究重组人白细胞介素-11(rhIL-11)应用于ICU病房血小板减少症患者的升血小板数量和改善血小板功能的临床疗效。方法:根据临床诊断将血小板计数〈70×10^9/L的60例患者按照随机数字表法分为rhIL-11组和对照组,每组30例。在常规治疗的基础上,rhIL-11组应用rhIL-11 1.5mg皮下注射,1次/d,当血小板数量升至100×10^9/L时停药;对照组注射等量生理盐水。观察2组用药前、用药后第3、5、7天血小板计数和凝血4项,以及用药前后血栓弹力图检测结果差异,并进行统计分析。结果:2组患者治疗前血小板计数差异无统计学意义,治疗后第5、7天rhIL-11组血小板计数明显高于对照组,2组差异有统计学意义。2组患者的性别、年龄、用药前后凝血4项(凝血酶原时间、活化部分凝血酶原时间、血浆凝血酶时间、纤维蛋白原)及血栓弹力图参数中的R时间、K时间、Angle角度、MA值均差异无统计学意义。rhIL-11组用药前后R、K、Angle差异无统计学意义,用药后MA较用药前增加,差异有统计学意义;rhIL-11组的有效率明显高于对照组;rhIL-11组无明显不良反应发生。结论:rhIL-11能够促进血小板减少症患者血小板数量的恢复,同时能显著改善血小板的功能,一定程度上可预防患者的出血,且疗效安全、可靠。 Objective:To study the relationship between thrombelatography variables in patients with thrombocytopenia after using recombinant human IL-11 (rhIL-11). Method: According to clinical diagnosis, 60 patients whose thrombocyte less than 70 ×10^9/L were randomly divided into the rhIL-11 group and control group. All the patients received active antibiotics and other comprehensive treatment. Patients in rhIL-11 group were given rhIL- 11 1.5 mg/d and patients in control group were given equivalent normal saline. Then we compared the results of platelet count,coagulation function and thrombelastography. Result:There were no significant differences between the two groups in gender, age, PT, APTT, TT, FIB and partial parameters of thrombelastograph, including K time, R time, Angle and MA. However in the rhIL-11 group, MA after the treatment was increased than that before the treatment. The difference in the platelet count before the treatment between the two groups was not statistically significant. The platelet count on the fifth or seventh day after the treatment was significantly higher in the rhIL-11 group than those in the control group, the difference was statistically significant. There were few adverse reactions in neither of the two groups. Conclusion:The rhIL-11 can promote the recovery of the platelet count and function in the ICU thrombocytopenia patients,with safe and reliable efficacy.
出处 《临床血液学杂志》 CAS 2016年第3期401-403,共3页 Journal of Clinical Hematology
基金 广西自然科学基金(No:2013GXNSFAA-019117) 广西自然科学基金(No:2012GXNSFBA-276036) 广西教委高校科研项目(No:201203YB046) 国家临床重点专科建设项目(No:2011-873)
关键词 重组人白细胞介素-11 血小板减少症 血栓弹力图 rhIL-11 thrombocytopenia thrombelastogrophy
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