胆道闭锁Kasai术后自体肝生存情况研究进展

Research progress on the survival of autologous liver in children with biliary atresia after Kasai operation

胆道闭锁(BA)是一种病因未明、以进行性炎症和纤维化为特征的阻塞性胆管病变。肝门-空肠吻合术(Kasai手术)是目前治疗BA的主要手术方式,但约80%的患儿Kasai术后效果不佳,继而需要行肝移植。影响BA患儿Kasai术后自体肝生存的因素有很多,包括BA分型、腹腔镜下Kasai手术、传统的开腹Kasai手术、患儿行Kasai术时年龄、术时肝脏病变情况、术后黄疸清除情况、胆管炎发生情况、术后是否使用激素以及是否中心化集中管理等,本文就影响BA患儿Kasai术后自体肝生存的这些因素的研究现状作一综述。

Biliary atresia (BA) is a kind of disease of unknown etiology, characterized by progressive inflammation and fibrosis of obstructive biliary diseases. Kasai portoenterostomy is the only method to treat BA. However, about 80% of the patients treated by Kasai operation still need liver transplantation in the future. Many factors affect the survival of autologous liver in children with BA after Kasai operation, including the types of BA, laparoscopic Kasai surgery or traditional open surgery, patient’s age at surgery, condition of liver function, occurrence of cholangitis, jaundice clearance, using steroids and central hospitalization. This article reviews the factors that affect the survival of autologous liver in patients with BA after Kasai surgery.