丹参多酚酸盐联合环磷腺苷葡胺对心绞痛患者PCI术后血粘度及炎性因子、NT-proBNP的影响

Effect of salvianolate combined with meglumine adenosine cyclphosphate on blood viscosity,inflammatory factors and NT-proBNP in angina pectoris patients after PCI

目的：研究丹参多酚酸盐联合环磷腺苷葡胺对心绞痛患者PCI术后血粘度及炎性因子、NTproBNP的影响。方法：选择2012年5月~2015年10月期间在我院接受PCI治疗的130例心绞痛患者进行研究,回顾分析患者的病历资料并根据PCI术后药物治疗方案不同分为实验组和对照组,实验组术后接受常规治疗联合丹参多酚酸盐、环磷腺苷葡胺治疗,对照组术后接受常规药物治疗。比较两者患者围手术期血粘度以及炎性因子、NT-proBNP含量的变化。结果：PCI术后,实验组患者的各项血粘度指标以及炎性因子、NT-proBNP含量均显著低于PCI术前、有显著性差异（P〈0.05）;对照组患者的各项血粘度指标与PCI术前比较无显著性差异（P〉0.05）,炎性因子、NT-proBNP含量均显著低于PCI术前、有显著性差异（P〈0.05）;PCI术后7天时,实验组患者的高切全血粘度、低切全血粘度、血浆粘度、聚集指数以及TNF-α、sICAM-1、sVCAM-1、LP-PLA2、NT-proBNP、D-二聚体、PTEN含量均显著低于对照组（P〈0.05）。结论：丹参多酚酸盐联合环磷腺苷葡胺能够降低心绞痛患者PCI术后的血粘度,同时能够减轻炎症反应、改善心脏泵血功能。

Objective：To study the effect of salvianolate combined with meglumine adenosine cyclphosphate on blood viscosity,inflammatory factors and NT-proBNP in angina pectoris patients after percutaneous coronary intervention （PCI）. Methods：A total of 130 angina pectoris patients who received PCI treatment in our hospital from May 2012 to October 201 5 were selected for study,patients＇medical records were retrospectively analyzed,they were divided into the experimental group and the control group based on the different medication schemes after PCI,experimental group received routine treatment com-bined with salvianolate and meglumine adenosine cyclphosphate treatment after operation,and control group received conven-tional medical treatment after operation.The changes of perioperative blood viscosity,inflammatory factor and NT-proBNP content were compared between two groups.Results：After PCI,the blood viscosity indexes as well as inflammatory factor and NT-proBNP levels of experimental group were significantly lower than those before PCI （P 〈0.05）;blood viscosity indexes ofnbsp;control group were not significantly different from those before PCI （P 〉0.05 ）,inflammatory factor and NT-proBNP levels were significantly lower than those before PCI （P 〈0.05）;7 days after PCI,the high-shear whole blood viscosity,low-shear whole blood viscosity,plasma viscosity and aggregation index as well as TNF-α,sICAM-1,sVCAM-1,LP-PLA2,NT-proB-NP,D-dimer and PTEN levels of experimental group were significantly lower than those of control group （P 〈0.05）.Conclu-sions：Salvianolate combined with meglumine adenosine cyclphosphate can reduce the blood viscosity of patients with angina pectoris after PCI,and can also reduce inflammation and improve heart pump function.