急性心肌梗死后左右心房重构的超声评价及其与血清指标的相关性研究

Ultrasonic evaluation of left and right atrial remodeling after acute myocardial infarction and its correlation with serum indexes

目的:分析急性心肌梗死后左右心房重构的超声评价及其与血清指标的相关性。方法:78例心肌梗死患者及82例正常体检者纳入本次研究,采用二维斑点追踪成像(2D-STI)检测心房重构参数值,采用酶联免疫吸附法(ELISA)测定血清心房重构标记物及心肌损伤相关指标水平。采用一元线性回归进一步分析心房重构参数值与血清指标水平的相关关系。结果:观察组的2D-STI下左房及右房SRs及Sre绝对值低于对照组,Sra绝对值高于对照组(P<0.05);观察组的血清APN、ⅠCTP、PⅢNP、HFABP、AOPP、ANP、hs-CRP水平高于对照组(P<0.05);SRs、Sre及Sra绝对值与血清APN、ⅠCTP、PⅢNP、H-FABP、AOPP、ANP、hs-CRP水平具有直接相关关系。结论:超声可以明确检测到急性心肌梗死后左右心房重构,且2D-STI与病情严重程度具有直接相关关系,可以作为指导临床治疗、评估预后的可靠方式。

Objective：To analyze the ultrasonic evaluation of left and right atrial remodeling after acute myocardial in-farction and its correlation with serum indexes.Methods：A total of 78 patients with myocardial infarction and 82 healthy sub-jects were included in this study,two-dimensional speckle tracking imaging （2D-STI）was used to detect atrial remodeling pa-rameter values,enzyme-linked immunosorbent assay （ELISA）was used to determine serum levels of atrial remodeling markers and myocardial injury-related parameters,and unary linear regression was used to further analyze the correlation between atrial remodeling parameter values and serum index levels.Results：Left atrial and right atrial SRs and absolute values of Sre under 2D-STI of observation group were lower than those of control group,and the absolute values of Sra were higher than those of control group （P 〈0.05 ）;serum APN,Ⅰ CTP,P Ⅲ NP,H-FABP,AOPP,ANP and hs-CRP levels of observation group were higher than those of control group （P 〈0.05）;SRs and the absolute values of Sre and Sra were directly correlated with serum APN,ⅠCTP,PⅢNP,H-FABP,AOPP,ANP and hs-CRP levels.Conclusion：Ultrasound can clearly detect the leftnbsp;and right atrial remodeling after acute myocardial infarction,and 2D-STI is directly correlated with the disease severity and can be a reliable way to guide clinical treatment and evaluate prognosis.